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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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GABAAalpha3 Receptor KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Spontaneous locomotor activity slightly increased but not
after amphetamine
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Gating:
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Disrupted PPI
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Response to APD:
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PPI defect improved by haloperidol Rx
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Citations:
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Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch
N, Dong Y, Malenka RC, Fritschy JM, Bluethmann H, Feldon J,
Möhler H, Rudolph U. A schizophrenia-related sensorimotor
deficit links alpha 3-containing GABAA receptors to a
dopamine hyperfunction. Proc Natl Acad Sci U S A . 2005 Nov
22 ; 102(47):17154-9.Abstract
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