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Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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FEZ1 KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Hyperactive; enhanced response to MK-801 and methamphetamine
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Molecular/morphological signature:
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Increased methamphetamine-induced DA release in nucleus
accumbens
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Citations:
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Sakae N, Yamasaki N, Kitaichi K, Fukuda T, Yamada M,
Yoshikawa H, Hiranita T, Tatsumi Y, Kira J, Yamamoto T,
Miyakawa T, Nakayama KI. Mice lacking the
schizophrenia-associated protein FEZ1 manifest hyperactivity
and enhanced responsiveness to psychostimulants. Hum Mol
Genet . 2008 Oct 15 ; 17(20):3191-203. Abstract
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