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Animal Models

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Animal Model: ErbB4 KO
Preparation Type: Genetic Preparations
DA-related behavior: Reduced spontaneous activity; hyperactivity in open field
Cognitive behavior: Reduced Morris water maze learning
Molecular/morphological signature: Reduced myelination, enhanced DA receptor expression
Citations: Golub MS, Germann SL, Lloyd KC. Behavioral characteristics of a nervous system-specific erbB4 knock-out mouse. Behav Brain Res. 2004 Aug 12; 153(1):159-70. Abstract

Roy K, Murtie JC, El-Khodor BF, Edgar N, Sardi SP, Hooks BM, Benoit-Marand M, Chen C, Moore H, O'Donnell P, Brunner D, Corfas G. Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders.Proc Natl Acad Sci U S A. 2007 May 8; 104(19):8131-6. Abstract

November 28, 2015
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