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Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Dysbindin-1, Sandy (sdy) Mouse
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Delayed hyperactivity in novel environment; less active in
open field
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Cognitive behavior:
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Object recognition deficit; impaired long-term memory
retention and working memory
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Social behavior:
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Decreased social interaction
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Molecular/morphological signature:
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DTNBP1 mutation with lack of dysbindin protein; increase in
DA metabolism in different brain regions; reduced snapin in
hippocampus; decreased DA levels in cortex, hippocampus and
hypothalamus; altered kinetics of transmitter release
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Citations:
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Murotani T, Ishizuka T, Hattori S, Hashimoto R, Matsuzaki S,
Yamatodani A. High dopamine turnover in the brains of Sandy
mice. Neurosci Lett . 2007 Jun 21 ; 421(1):47-51. Abstract
Bhardwaj SK, Baharnoori M, Sharif-Askari B, Kamath
A, Williams S, Srivastava LK. Behavioral characterization of
dysbindin-1 deficient sandy mice. Behav Brain Res . 2009 Feb
11 ; 197(2):435-41. Abstract
Takao K, Toyama K, Nakanishi K, Hattori S, Takamura
H, Takeda M, Miyakawa T, Hashimoto R. Impaired long-term
memory retention and working memory in sdy mutant mice with
a deletion in Dtnbp1, a susceptibility gene for
schizophrenia. Mol Brain . 2008 Jan 1 ; 1(1):11.
Abstract
Feng YQ, Zhou ZY, He X, Wang H, Guo XL, Hao CJ, Guo
Y, Zhen XC, Li W. Dysbindin deficiency in sandy mice causes
reduction of snapin and displays behaviors related to
schizophrenia. Schizophr Res . 2008 Dec 1 ; 106(2-3):218-28.
Abstract
Hattori S, Murotani T, Matsuzaki S, Ishizuka T,
Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H,
Hashimoto R. Behavioral abnormalities and dopamine
reductions in sdy mutant mice with a deletion in Dtnbp1, a
susceptibility gene for schizophrenia. Biochem Biophys Res
Commun . 2008 Aug 22 ; 373(2):298-302.
Abstract
Chen XW, Feng YQ, Hao CJ, Guo XL, He X, Zhou ZY, Guo
N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W, Zhou
Z. DTNBP1, a schizophrenia susceptibility gene, affects
kinetics of transmitter release. J Cell Biol . 2008 Jun 2 ;
181(5):791-801. Abstract
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