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Animal Models

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Animal Model: Dysbindin-1, Sandy (sdy) Mouse
Preparation Type: Genetic Preparations
DA-related behavior: Delayed hyperactivity in novel environment; less active in open field
Cognitive behavior: Object recognition deficit; impaired long-term memory retention and working memory
Social behavior: Decreased social interaction
Molecular/morphological signature: DTNBP1 mutation with lack of dysbindin protein; increase in DA metabolism in different brain regions; reduced snapin in hippocampus; decreased DA levels in cortex, hippocampus and hypothalamus; altered kinetics of transmitter release
Citations: Murotani T, Ishizuka T, Hattori S, Hashimoto R, Matsuzaki S, Yamatodani A. High dopamine turnover in the brains of Sandy mice. Neurosci Lett . 2007 Jun 21 ; 421(1):47-51. Abstract

Bhardwaj SK, Baharnoori M, Sharif-Askari B, Kamath A, Williams S, Srivastava LK. Behavioral characterization of dysbindin-1 deficient sandy mice. Behav Brain Res . 2009 Feb 11 ; 197(2):435-41. Abstract

Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M, Miyakawa T, Hashimoto R. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain . 2008 Jan 1 ; 1(1):11. Abstract

Feng YQ, Zhou ZY, He X, Wang H, Guo XL, Hao CJ, Guo Y, Zhen XC, Li W. Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia. Schizophr Res . 2008 Dec 1 ; 106(2-3):218-28. Abstract

Hattori S, Murotani T, Matsuzaki S, Ishizuka T, Kumamoto N, Takeda M, Tohyama M, Yamatodani A, Kunugi H, Hashimoto R. Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Biochem Biophys Res Commun . 2008 Aug 22 ; 373(2):298-302. Abstract

Chen XW, Feng YQ, Hao CJ, Guo XL, He X, Zhou ZY, Guo N, Huang HP, Xiong W, Zheng H, Zuo PL, Zhang CX, Li W, Zhou Z. DTNBP1, a schizophrenia susceptibility gene, affects kinetics of transmitter release. J Cell Biol . 2008 Jun 2 ; 181(5):791-801. Abstract


July 26, 2014
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