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product or therapy. ALL medications and supplements
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Animal Model:
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Dopamine Transporter KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Increased DA and decreased D1R, D2R,
hyperactive
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Gating:
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Disrupted PPI
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Cognitive behavior:
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Impaired adaption to environmental changes in Morris water maze
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Social behavior:
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Impaired social behavior
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Molecular/morphological signature:
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Decreased LTD in hippocampus
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Response to APD:
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More aggressive; impairments in Morris water maze reversed
by haloperidol and acute nicotine treatment; LTD reversed by
haloperidol
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Citations:
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Trinh JV, Nehrenberg DL, Jacobsen JP, Caron MG, Wetsel WC.
Differential psychostimulant-induced activation of neural
circuits in dopamine transporter knockout and wild type
mice. Neuroscience . 2003 Jan 1 ; 118(2):297-310. Abstract
Rodriguiz RM, Chu R, Caron MG, Wetsel WC. Aberrant
responses in social interaction of dopamine transporter
knockout mice. Behav Brain Res . 2004 Jan 5 ;
148(1-2):185-98. Abstract
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