Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Animal Models

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Animal Model: DBA/2
Preparation Type: Genetic Preparations
Gating: Disrupted N40 gating and PPI
Molecular/morphological signature: Decreased levels Glu, tau and GABA in hippocampus
Response to APD: Phenotype reversed by a7-nicotinic and α4β2 receptor agonist; by olanzapine via alpha7-nicotinic receptor; by gestational choline supplementation; by baclofen and clozapine
Citations: Stevens KE, Kem WR, Mahnir VM, Freedman R. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl) . 1998 Apr 1 ; 136(4):320-7. Abstract

Shubenina EB, Kudrin VS, Klodt PM, Pokrovskii AA, Gudasheva TA, Voronina TA, Ostrovskaia RU. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksp Klin Farmakol. 2008 Jul-Aug; 71(4):7-10. Abstract

Simosky JK, Freedman R, Stevens KE. Olanzapine improves deficient sensory inhibition in DBA/2 mice. Brain Res. 2008 Oct 3; 1233():129-36. Abstract

Wildeboer KM, Stevens KE. Stimulation of the alpha4beta2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice. Brain Res. 2008 Aug 11; 1224():29-36. Abstract

Stevens KE, Adams CE, Yonchek J, Hickel C, Danielson J, Kisley MA. Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline. Psychopharmacology (Berl). 2008 Jun; 198(3):413-20. Abstract

Bortolato M, Frau R, Orru M, Piras AP, Fa M, Tuveri A, Puligheddu M, Gessa GL, Castelli MP, Mereu G, Marrosu F. Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice. Psychopharmacology (Berl). 2007 Oct; 194(3):361-9. Abstract

July 29, 2016
SRF News
SRF Comments
Text Size
Reset Text Size

Check out our most recent webinar, Studying Psychosis in 22q11 Deletion Syndrome.

See our webinar, The Baby and the Bathwater: Signal and Noise in Psychiatric Neuroimaging.
Copyright © 2005- 2016 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright