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product or therapy. ALL medications and supplements
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due to the possibility of side-effects, drug interactions,
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Animal Model:
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DBA/2 Mouse
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Preparation Type:
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Genetic Preparations
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Gating:
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Disrupted N40 gating and PPI
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Molecular/morphological signature:
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Decreased levels Glu, tau and GABA in hippocampus
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Response to APD:
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Phenotype reversed by a7-nicotinic and α4β2 receptor
agonist; by olanzapine via alpha7-nicotinic receptor; by
gestational choline supplementation; by baclofen and clozapine
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Citations:
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Stevens KE, Kem WR, Mahnir VM, Freedman R. Selective
alpha7-nicotinic agonists normalize inhibition of auditory
response in DBA mice. Psychopharmacology (Berl) . 1998 Apr 1
; 136(4):320-7. Abstract
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