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Animal Models

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Animal Model: DBA/2
Preparation Type: Genetic Preparations
Gating: Disrupted N40 gating and PPI
Molecular/morphological signature: Decreased levels Glu, tau and GABA in hippocampus
Response to APD: Phenotype reversed by a7-nicotinic and α4β2 receptor agonist; by olanzapine via alpha7-nicotinic receptor; by gestational choline supplementation; by baclofen and clozapine
Citations: Stevens KE, Kem WR, Mahnir VM, Freedman R. Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology (Berl) . 1998 Apr 1 ; 136(4):320-7. Abstract

Shubenina EB, Kudrin VS, Klodt PM, Pokrovskii AA, Gudasheva TA, Voronina TA, Ostrovskaia RU. [Interstrain differences in the content of excitatory and inhibitory amino acids in the brain of DBA/2J, Balb/c and C57BL/6 mice: characteristics of the effect of a dipeptide antipsychotic drug dilept]. Eksp Klin Farmakol. 2008 Jul-Aug; 71(4):7-10. Abstract

Simosky JK, Freedman R, Stevens KE. Olanzapine improves deficient sensory inhibition in DBA/2 mice. Brain Res. 2008 Oct 3; 1233():129-36. Abstract

Wildeboer KM, Stevens KE. Stimulation of the alpha4beta2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice. Brain Res. 2008 Aug 11; 1224():29-36. Abstract

Stevens KE, Adams CE, Yonchek J, Hickel C, Danielson J, Kisley MA. Permanent improvement in deficient sensory inhibition in DBA/2 mice with increased perinatal choline. Psychopharmacology (Berl). 2008 Jun; 198(3):413-20. Abstract

Bortolato M, Frau R, Orru M, Piras AP, Fa M, Tuveri A, Puligheddu M, Gessa GL, Castelli MP, Mereu G, Marrosu F. Activation of GABA(B) receptors reverses spontaneous gating deficits in juvenile DBA/2J mice. Psychopharmacology (Berl). 2007 Oct; 194(3):361-9. Abstract


December 19, 2014
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