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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Catecholamine O-methyl transferase (COMT) KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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No potentiation of amphetamine-induced locomotion
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Cognitive behavior:
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Impaired recognition memory in heterozygous only
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Social behavior:
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No deficit in sociability or social novelty in KO or hets
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Molecular/morphological signature:
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Increased DOPAC, D1 and D2 unchanged
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Response to APD:
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Increased anxiety and aggression
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Citations:
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Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D,
Karayiorgou M. Catechol-O-methyltransferase-deficient mice
exhibit sexually dimorphic changes in catecholamine levels
and behavior. Proc Natl Acad Sci U S A . 1998 Aug 18 ;
95(17):9991-6. Abstract
Huotari M, García-Horsman JA, Karayiorgou M, Gogos
JA, Männistö PT. D-amphetamine responses in
catechol-O-methyltransferase (COMT) disrupted mice.
Psychopharmacology (Berl) . 2004 Feb 1 ; 172(1):1-10. Abstract
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