 |
|
|
Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
|
Animal Model:
|
Calcineurin Agamma KO
|
|
Preparation Type:
|
Genetic Preparations
|
|
DA-related behavior:
|
Enhanced response to amphetamine
|
|
Gating:
|
Disrupted PPI and latent inhibition
|
|
Cognitive behavior:
|
Disrupted PPI and latent inhibition
|
|
Social behavior:
|
Impaired social interaction
|
|
Molecular/morphological signature:
|
Inducible KO
|
|
Citations:
|
Miyakawa T, Leiter LM, Gerber DJ, Gainetdinov RR, Sotnikova
TD, Zeng H, Caron MG, Tonegawa S. Conditional calcineurin
knockout mice exhibit multiple abnormal behaviors related to
schizophrenia. Proc Natl Acad Sci U S A . 2003 Jul 22 ;
100(15):8987-92. Abstract
|
|
|
|
|
|
Text Size 
See our most recent Schizophrenia Bulletin theme Webinar: