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Animal Model:
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BACE1 KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Increased novelty-induced hyperactivity; hypersensitivity to
locomotor effects of MK-801
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Gating:
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PPI deficits
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Cognitive behavior:
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Working memory deficits; impaired in inhibitory avoidance task
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Social behavior:
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Alterations in social recognition
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Molecular/morphological signature:
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Impaired processing of NRG1; decreased spine density and
mature spines in CA1
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Response to APD:
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Clozapine attenuates novelty-induced hyperactivity and
normalizes PPI deficits
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Citations:
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Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL,
Wong PC. Alteration of BACE1-dependent NRG1/ErbB4 signaling
and schizophrenia-like phenotypes in BACE1-null mice. Proc
Natl Acad Sci U S A . 2008 Apr 8 ; 105(14):5585-90. Abstract
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