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Animal Models

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Animal Model: BACE1 KO
Preparation Type: Genetic Preparations
DA-related behavior: Increased novelty-induced hyperactivity; hypersensitivity to locomotor effects of MK-801
Gating: PPI deficits
Cognitive behavior: Working memory deficits; impaired in inhibitory avoidance task
Social behavior: Alterations in social recognition
Molecular/morphological signature: Impaired processing of NRG1; decreased spine density and mature spines in CA1
Response to APD: Clozapine attenuates novelty-induced hyperactivity and normalizes PPI deficits
Citations: Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC. Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice. Proc Natl Acad Sci U S A . 2008 Apr 8 ; 105(14):5585-90. Abstract


August 30, 2014
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