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Animal Model:
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Apomorphine Susceptible Rat
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Enhanced locomotor response to novel open field
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Gating:
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Disrupted PPI and diminished latent inhibition; Visual and
acoustic PPI deficits; Sprague-Dawley rats more sensitive t
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Molecular/morphological signature:
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Preferential mobilization of NMDAR NR1 subunits in D1R
containing neurons of the nucleus accumbens
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Citations:
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Ellenbroek BA, Cools AR. Apomorphine susceptibility and
animal models for psychopathology: genes and environment.
Behav Genet . 2002 Sep 1 ; 32(5):349-61. Abstract
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