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Animal Models

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Animal Model: AMPAR GluR1 Subunit KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive, no effect of MK-801 on locomotor behavior
Gating: PPI deficit
Cognitive behavior: Disrupted spatial working memory
Social behavior: Disorganized social behaviors
Molecular/morphological signature: Slowed extracellular DA clearance in striatum
Response to APD: Anxiety prone; Hyperactivity reversed by haloperidol
Citations: Bannerman DM, Deacon RM, Brady S, Bruce A, Sprengel R, Seeburg PH, Rawlins JN. A comparison of GluR-A-deficient and wild-type mice on a test battery assessing sensorimotor, affective, and cognitive behaviors. Behav Neurosci . 2004 Jun 1 ; 118(3):643-7. Abstract

Wiedholz LM, Owens WA, Horton RE, Feyder M, Karlsson RM, Hefner K, Sprengel R, Celikel T, Daws LC, Holmes A. Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors. Mol Psychiatry . 2008 Jun 1 ; 13(6):631-40. Abstract


September 30, 2014
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