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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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NMDA Receptor Antagonist Rx (MK801, PCP, Ketamine)-Acute
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Preparation Type:
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Drug-Induced Preparations
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DA-related behavior:
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Increases locomotor activity and stereotopy, ataxia
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Gating:
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Disrupted PPI 1 day after PCP, and 15 minutes after PCP, but
not 7 or 28 days later, abnormal latent inhibition
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Cognitive behavior:
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Decreased working memory, disrupted fear conditioning,
long-term spatial memory deficits, impaired
passive-avoidance, recognition memory deficit
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Social behavior:
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Impaired social interaction
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Molecular/morphological signature:
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Impaired LTP, decreased AMPA receptor density
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Response to APD:
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Enhanced locomotor responses blocked by APD, glycine
transporter-1 inhibition rescues LTP, PPI disruption
attenuated by admatine, glycine, D-serine, not
D-cycloserine, fear conditioning disruption prevented by
clozapine, but not haloperidol, LI abnormalities reversed by
risperidone and M100907, passive avoidance impairment
reversed by lurasidone, recognition memory deficit reversed
by clozapine and D-serine, but not haloperidol
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