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Animal Models

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Animal Model: NMDA Receptor Antagonist Rx (MK801, PCP, Ketamine)-Acute, Rodent
Preparation Type: Drug-Induced Preparations
DA-related behavior: Increases locomotor activity and stereotopy, ataxia
Gating: Disrupted PPI 1 day after PCP, and 15 minutes after PCP, but not 7 or 28 days later, abnormal latent inhibition
Cognitive behavior: Decreased working memory, disrupted fear conditioning, long-term spatial memory deficits, impaired passive-avoidance, recognition memory deficit
Social behavior: Impaired social interaction
Molecular/morphological signature: Impaired LTP, decreased AMPA receptor density
Response to APD: Enhanced locomotor responses blocked by APD, glycine transporter-1 inhibition rescues LTP, PPI disruption attenuated by admatine, glycine, D-serine, not D-cycloserine, fear conditioning disruption prevented by clozapine, but not haloperidol, LI abnormalities reversed by risperidone and M100907, passive avoidance impairment reversed by lurasidone, recognition memory deficit reversed by clozapine and D-serine, but not haloperidol
Citations: Jentsch JD, Roth RH. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology. 1999 Mar 1; 20(3):201-25. Abstract

Manahan-Vaughan, D., D. von Haebler, C. Winter, G. Juckel, and U. Heinemann, A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats. Hippocampus, 2008. 18(2): p. 125-34. Abstract

Manahan-Vaughan, D., V. Wildforster, and C. Thomsen, Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1). Eur J Neurosci, 2008. 28(7): p. 1342-50. Abstract

Gaisler-Salomon, I., L. Diamant, C. Rubin, and I. Weiner, Abnormally persistent latent inhibition induced by MK801 is reversed by risperidone and by positive modulators of NMDA receptor function: differential efficacy depending on the stage of the task at which they are administered. Psychopharmacology (Berl), 2008. 196(2): p. 255-67. Abstract

Kanahara, N., E. Shimizu, S. Ohgake, Y. Fujita, M. Kohno, T. Hashimoto, D. Matsuzawa, Y. Shirayama, K. Hashimoto, and M. Iyo, Glycine and D: -serine, but not D: -cycloserine, attenuate prepulse inhibition deficits induced by NMDA receptor antagonist MK-801. Psychopharmacology (Berl), 2008. 198(3): p. 363-74. Abstract

Karasawa, J., K. Hashimoto, and S. Chaki, D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats. Behav Brain Res, 2008. 186(1): p. 78-83. Abstract

Ishiyama, T., K. Tokuda, T. Ishibashi, A. Ito, S. Toma, and Y. Ohno, Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test. Eur J Pharmacol, 2007. 572(2-3): p. 160-70. Abstract

Palsson, E., K. Fejgin, C. Wass, and D. Klamer, Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition. Eur J Pharmacol, 2008. 590(1-3): p. 212-6. Abstract

Pietersen, C.Y., F.J. Bosker, J. Doorduin, M.E. Jongsma, F. Postema, J.V. Haas, M.P. Johnson, T. Koch, T. Vladusich, and J.A. den Boer, An animal model of emotional blunting in schizophrenia. PLoS ONE, 2007. 2(12): p. e1360. Abstract

Zavitsanou, K., V. Nguyen, K. Newell, P. Ballantyne, and X.F. Huang, Rapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: implications for schizophrenia. J Chem Neuroanat, 2008. 36(2): p. 71-6. Abstract

July 29, 2016
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