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Animal Model:
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Disinhibition of Ventral Hippocampus
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Preparation Type:
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Drug-Induced Preparations
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DA-related behavior:
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Increased locomotor activity
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Gating:
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Disrupted PPI
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Cognitive behavior:
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Disrupted fear conditioning
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Molecular/morphological signature:
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Increased accumbens and cortex dopamine
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Response to APD:
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Haloperidol and clozapine block hyperactivity but no effect
on PPI deficit
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