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Animal Models

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Animal Model: Rodent Prenatal Immune Challenge: PolyI:C (delivery timing varies)
Preparation Type: Developmental Preparations
DA-related behavior: No change in total distance traveled in open field but reduced center exploration; increased response to amphetamine and MK-801 (emerges after puberty)--not rescued by cross-fostering
Gating: Disrupted PPI and changes in latent inhibition (post-puberty); PPI deficit not rescued by cross-fostering
Cognitive behavior: Reduced escape latency in Morris water maze; impairment n novel object recognition memory and latent inhibition (post-puberty); classical fear conditioning, active avoidance and discrimination learning appear normal
Social behavior: Reduced social interaction
Molecular/morphological signature: Amphetamine-induced DA release increased; increased hippocampal pyknotic cells; increased DA turnover and reduced binding to D2 receptors in striatum; reduced reelin- and parvalbumin- expressing neurons in PFC; reduced D1 receptors in PFC; increased TH expression in striatum; reduced density of cerebellar Purkinje cells; delayed myelination of hippocampus
Response to APD: Deficits in latent inhibition and novel object recognition memory are improved by clozapine but not haloperidol

October 31, 2014
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See our upcoming webinar, Cognition and Treatment Resistance in Schizophrenia, to be held Monday, November 10, 12:00 to 1:30 p.m. EST.

See our last webinar, Research Domain Criteria (RDoC) Applied to Verbal Hallucinations, held May 28, 2014.

Check out our Schizophrenia Bulletin Forum Discussion: Prefrontal Inefficiency Is Associated With Polygenic Risk for Schizophrenia.
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