Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Animal Models

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Animal Model: Rodent Prenatal Immune Challenge: PolyI:C (delivery timing varies)
Preparation Type: Developmental Preparations
DA-related behavior: No change in total distance traveled in open field but reduced center exploration; increased response to amphetamine and MK-801 (emerges after puberty)--not rescued by cross-fostering
Gating: Disrupted PPI and changes in latent inhibition (post-puberty); PPI deficit not rescued by cross-fostering
Cognitive behavior: Reduced escape latency in Morris water maze; impairment n novel object recognition memory and latent inhibition (post-puberty); classical fear conditioning, active avoidance and discrimination learning appear normal
Social behavior: Reduced social interaction
Molecular/morphological signature: Amphetamine-induced DA release increased; increased hippocampal pyknotic cells; increased DA turnover and reduced binding to D2 receptors in striatum; reduced reelin- and parvalbumin- expressing neurons in PFC; reduced D1 receptors in PFC; increased TH expression in striatum; reduced density of cerebellar Purkinje cells; delayed myelination of hippocampus
Response to APD: Deficits in latent inhibition and novel object recognition memory are improved by clozapine but not haloperidol


October 24, 2014
SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Share/Bookmark

Check out our Schizophrenia Bulletin Forum Discussion: Prefrontal Inefficiency Is Associated With Polygenic Risk for Schizophrenia.
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright