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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Rat Prenatal Vitamin D Insufficiency
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Preparation Type:
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Developmental Preparations
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DA-related behavior:
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Enhanced MK-801induced locomotion; enhanced
amphetamine-induced locomotion (females only)
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Gating:
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No disruption in PPI
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Social behavior:
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No deficit in social behavior
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Molecular/morphological signature:
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Enlarged lateral ventricles; thinned cortex; altered brain
expression of proteins involved in mitochondrial function,
calcium homeostasis, and synaptic plasticity; decreased
neurogenesis
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Response to APD:
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Haloperidol ameliorated effects on neurogenesis
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Citations:
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Kesby JP, Burne TH, McGrath JJ, Eyles DW. Developmental
vitamin D deficiency alters MK 801-induced hyperlocomotion
in the adult rat: An animal model of schizophrenia. Biol
Psychiatry . 2006 Sep 15 ; 60(6):591-6. Abstract
Eyles DW, Rogers F, Buller K, McGrath JJ, Ko P,
French K, Burne TH. Developmental vitamin D (DVD) deficiency
in the rat alters adult behaviour independently of HPA
function. Psychoneuroendocrinology . 2006 Sep 1 ;
31(8):958-64. Abstract
Eyles D, Almeras L, Benech P, Patatian A, Mackay-Sim
A, McGrath J, Féron F. Developmental vitamin D deficiency
alters the expression of genes encoding mitochondrial,
cytoskeletal and synaptic proteins in the adult rat brain. J
Steroid Biochem Mol Biol . 2007 Mar 1 ; 103(3-5):538-45.
Abstract
Féron F, Burne TH, Brown J, Smith E, McGrath JJ,
Mackay-Sim A, Eyles DW. Developmental Vitamin D3 deficiency
alters the adult rat brain. Brain Res Bull . 2005 Mar 15 ;
65(2):141-8. Abstract
Almeras L, Eyles D, Benech P, Laffite D, Villard C,
Patatian A, Boucraut J, Mackay-Sim A, McGrath J, Féron F.
Developmental vitamin D deficiency alters brain protein
expression in the adult rat: implications for
neuropsychiatric disorders. Proteomics . 2007 Mar 1 ;
7(5):769-80. Abstract
McGrath J, Iwazaki T, Eyles D, Burne T, Cui X, Ko P,
Matsumoto I. Protein expression in the nucleus accumbens of
rats exposed to developmental vitamin D deficiency. PLoS ONE
. 2008 Jan 1 ; 3(6):e2383. Abstract
Harms LR, Eyles DW, McGrath JJ, Mackay-Sim A, Burne
TH. Developmental vitamin D deficiency alters adult
behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res .
2008 Mar 5 ; 187(2):343-50. Abstract
Keilhoff G, Grecksch G, Becker A. Haloperidol
normalized prenatal vitamin D depletion-induced reduction of
hippocampal cell proliferation in adult rats. Neurosci Lett
. 2010 May 31 ; 476(2):94-8. Abstract
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