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Animal Models

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Animal Model: Rat Prenatal Vitamin D Insufficiency
Preparation Type: Developmental Preparations
DA-related behavior: Enhanced MK-801induced locomotion; enhanced amphetamine-induced locomotion (females only)
Gating: No disruption in PPI
Social behavior: No deficit in social behavior
Molecular/morphological signature: Enlarged lateral ventricles; thinned cortex; altered brain expression of proteins involved in mitochondrial function, calcium homeostasis, and synaptic plasticity; decreased neurogenesis
Response to APD: Haloperidol ameliorated effects on neurogenesis
Citations: Kesby JP, Burne TH, McGrath JJ, Eyles DW. Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia. Biol Psychiatry . 2006 Sep 15 ; 60(6):591-6. Abstract

Eyles DW, Rogers F, Buller K, McGrath JJ, Ko P, French K, Burne TH. Developmental vitamin D (DVD) deficiency in the rat alters adult behaviour independently of HPA function. Psychoneuroendocrinology . 2006 Sep 1 ; 31(8):958-64. Abstract

Eyles D, Almeras L, Benech P, Patatian A, Mackay-Sim A, McGrath J, Féron F. Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. J Steroid Biochem Mol Biol . 2007 Mar 1 ; 103(3-5):538-45. Abstract

Féron F, Burne TH, Brown J, Smith E, McGrath JJ, Mackay-Sim A, Eyles DW. Developmental Vitamin D3 deficiency alters the adult rat brain. Brain Res Bull . 2005 Mar 15 ; 65(2):141-8. Abstract

Almeras L, Eyles D, Benech P, Laffite D, Villard C, Patatian A, Boucraut J, Mackay-Sim A, McGrath J, Féron F. Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics . 2007 Mar 1 ; 7(5):769-80. Abstract

McGrath J, Iwazaki T, Eyles D, Burne T, Cui X, Ko P, Matsumoto I. Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency. PLoS ONE . 2008 Jan 1 ; 3(6):e2383. Abstract

Harms LR, Eyles DW, McGrath JJ, Mackay-Sim A, Burne TH. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res . 2008 Mar 5 ; 187(2):343-50. Abstract

Keilhoff G, Grecksch G, Becker A. Haloperidol normalized prenatal vitamin D depletion-induced reduction of hippocampal cell proliferation in adult rats. Neurosci Lett . 2010 May 31 ; 476(2):94-8. Abstract


September 3, 2014
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