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Animal Models

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Animal Model: Rat Prenatal Immune Challenge: LPS
Preparation Type: Developmental Preparations
DA-related behavior: Increased amphetamine-induced locomotion
Gating: Enhanced acoustic startle; disrupted PPI (worse in males)
Cognitive behavior: Impaired object recognition (post-puberty)
Social behavior: Reduced social interaction, possibly due to increased anxiety
Molecular/morphological signature: Reduced dendritic complexity in PFC and hippocampus; increased accumbal DA and striatal DOPAC; elevated serum and fetal brain cytokine levels; altered frontal synaptophysin expression; reduced parvalbumin-expressing neurons in the hippocampus; down regulated expression of several genes involved in neurogenesis and neuronal migration; (direction of some changes are age-dependent)
Response to APD: PPI deficit and elevated serum cytokines both reversed by haloperidol
Citations: Borrell J, Vela JM, Arévalo-Martin A, Molina-Holgado E, Guaza C. Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology . 2002 Feb 1 ; 26(2):204-15. Abstract

Baharnoori M, Brake WG, Srivastava LK. Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats. Schizophr Res . 2009 Jan 1 ; 107(1):99-109. Abstract

Fortier ME, Joober R, Luheshi GN, Boksa P. Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring. J Psychiatr Res . 2004 May-Jun ; 38(3):335-45. Abstract

Fortier ME, Luheshi GN, Boksa P. Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy. Behav Brain Res . 2007 Aug 6 ; 181(2):270-7. Abstract

Hava G, Vered L, Yael M, Mordechai H, Mahoud H. Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy. Dev Psychobiol . 2006 Mar 1 ; 48(2):162-8. Abstract

Romero E, Ali C, Molina-Holgado E, Castellano B, Guaza C, Borrell J. Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics. Neuropsychopharmacology . 2007 Aug 1 ; 32(8):1791-804. Abstract

Romero E, Guaza C, Castellano B, Borrell J. Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia. Mol Psychiatry . 2008 Apr 15. Abstract

Jenkins TA, Harte MK, Stenson G, Reynolds GP. Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat. Behav Brain Res . 2009 Dec 28 ; 205(2):355-9. Abstract

Oskvig DB, Elkahloun AG, Johnson KR, Phillips TM, Herkenham M. Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response. Brain Behav Immun . 2012 May ; 26(4):623-34. Abstract


October 24, 2014
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