Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Animal Models

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Animal Model: Placental Insufficiency/Birth Insults, Rat
Preparation Type: Developmental Preparations
DA-related behavior: Enhanced amphetamine-induced locomotion and accumbal dopamine release
Gating: Disrupted PPI (post-pubertal onset)
Cognitive behavior: Performance on Morris water maze and T-maze appears normal
Molecular/morphological signature: Reduced DA release in PFC, increased DAT in NAc (basal), decreased DA receptor expression; reduced dentate granule cells; region- and age-specific alterations in dendritic spine development; altered expression of presynaptic genes; decreased caudate-putamen volume
Response to APD: PPI deficits reversed by clozapine
Citations: Boksa P. Animal models of obstetric complications in relation to schizophrenia. Brain Res Brain Res Rev . 2004 Apr 1 ; 45(1):1-17. Abstract

Hoeger H, Engelmann M, Bernert G, Seidl R, Bubna-Littitz H, Mosgoeller W, Lubec B, Lubec G. Long term neurological and behavioral effects of graded perinatal asphyxia in the rat. Life Sci . 2000 Jan 1 ; 66(10):947-62. Abstract

Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto S, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N. Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. PLoS ONE . 2008 Jan 1 ; 3(11):e3648. Abstract

Juárez I, Gratton A, Flores G. Ontogeny of altered dendritic morphology in the rat prefrontal cortex, hippocampus, and nucleus accumbens following Cesarean delivery and birth anoxia. J Comp Neurol . 2008 Apr 10 ; 507(5):1734-47. Abstract

Fendt M, Lex A, Falkai P, Henn FA, Schmitt A. Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: implications for schizophrenia. Pharmacopsychiatry . 2008 Jul ; 41(4):138-45. Abstract

Sommer JU, Schmitt A, Heck M, Schaeffer EL, Fendt M, Zink M, Nieselt K, Symons S, Petroianu G, Lex A, Herrera-Marschitz M, Spanagel R, Falkai P, Gebicke-Haerter PJ. Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia. Eur Arch Psychiatry Clin Neurosci . 2010 Nov ; 260 Suppl 2():S81-9. Abstract

Schaeffer EL, Kühn F, Schmitt A, Gattaz WF, Gruber O, Schneider-Axmann T, Falkai P, Schmitt A. Increased cell proliferation in the rat anterior cingulate cortex following neonatal hypoxia: relevance to schizophrenia. J Neural Transm . 2013 Jan ; 120(1):187-95. Abstract

July 27, 2016
SRF News
SRF Comments
Text Size
Reset Text Size

Check out our upcoming webinar, Studying Psychosis in 22q11 Deletion Syndrome, Thursday, July 28, 2016, 1-2:30 p.m. EDT.

See our recent webinar, The Baby and the Bathwater: Signal and Noise in Psychiatric Neuroimaging.
Copyright © 2005- 2016 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright