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Animal Models

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Animal Model: Rat Placental Insufficiency/Birth Insults
Preparation Type: Developmental Preparations
DA-related behavior: Enhanced amphetamine-induced locomotion and accumbal dopamine release
Gating: Disrupted PPI (post-pubertal onset)
Cognitive behavior: Performance on Morris water maze and T-maze appears normal
Molecular/morphological signature: Reduced DA release in PFC, increased DAT in NAc (basal), decreased DA receptor expression; reduced dentate granule cells; region- and age-specific alterations in dendritic spine development; altered expression of presynaptic genes; decreased caudate-putamen volume
Response to APD: PPI deficits reversed by clozapine
Citations: Boksa P. Animal models of obstetric complications in relation to schizophrenia. Brain Res Brain Res Rev . 2004 Apr 1 ; 45(1):1-17. Abstract

Hoeger H, Engelmann M, Bernert G, Seidl R, Bubna-Littitz H, Mosgoeller W, Lubec B, Lubec G. Long term neurological and behavioral effects of graded perinatal asphyxia in the rat. Life Sci . 2000 Jan 1 ; 66(10):947-62. Abstract

Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto S, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N. Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. PLoS ONE . 2008 Jan 1 ; 3(11):e3648. Abstract

Juárez I, Gratton A, Flores G. Ontogeny of altered dendritic morphology in the rat prefrontal cortex, hippocampus, and nucleus accumbens following Cesarean delivery and birth anoxia. J Comp Neurol . 2008 Apr 10 ; 507(5):1734-47. Abstract

Fendt M, Lex A, Falkai P, Henn FA, Schmitt A. Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: implications for schizophrenia. Pharmacopsychiatry . 2008 Jul ; 41(4):138-45. Abstract

Sommer JU, Schmitt A, Heck M, Schaeffer EL, Fendt M, Zink M, Nieselt K, Symons S, Petroianu G, Lex A, Herrera-Marschitz M, Spanagel R, Falkai P, Gebicke-Haerter PJ. Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia. Eur Arch Psychiatry Clin Neurosci . 2010 Nov ; 260 Suppl 2():S81-9. Abstract

Schaeffer EL, Kühn F, Schmitt A, Gattaz WF, Gruber O, Schneider-Axmann T, Falkai P, Schmitt A. Increased cell proliferation in the rat anterior cingulate cortex following neonatal hypoxia: relevance to schizophrenia. J Neural Transm . 2013 Jan ; 120(1):187-95. Abstract


August 30, 2014
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