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Animal Models

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Animal Model: Rat Neonatal Immune Challenge: Borna Disease Virus
Preparation Type: Developmental Preparations
DA-related behavior: Enhanced novelty induced locomotor activity in Fisher rats; enhanced amphetamine-induced locomotion
Gating: Disrupted PPI in Fisher rats
Cognitive behavior: Reduced social interaction
Molecular/morphological signature: Impairs BDNF synaptogenesis; prefrontal cortex thinning; loss of cerebellar Purkinje neurons; increased norepinephrine and 5-HT levels in cortex and cerebellum (post-pubertal)
Citations: Solbrig MV, Koob GF, Parsons LH, Kadota T, Horscroft N, Briese T, Lipkin WI. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability. J Neurosci . 2000 Nov 1 ; 20(21):RC104. Abstract

Pletnikov MV, Rubin SA, Vogel MW, Moran TH, Carbone KM. Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. I. Brain pathology and behavioral deficits. Brain Res . 2002 Jul 19 ; 944(1-2):97-107. Abstract

Hans A, Bajramovic JJ, Syan S, Perret E, Dunia I, Brahic M, Gonzalez-Dunia D. Persistent, noncytolytic infection of neurons by Borna disease virus interferes with ERK 1/2 signaling and abrogates BDNF-induced synaptogenesis. FASEB J . 2004 May 1 ; 18(7):863-5. Abstract

Pletnikov MV, Rubin SA, Schwartz GJ, Carbone KM, Moran TH. Effects of neonatal rat Borna disease virus (BDV) infection on the postnatal development of the brain monoaminergic systems. Brain Res Dev Brain Res . 2000 Feb 7 ; 119(2):179-85. Abstract

Eisenman LM, Brothers R, Tran MH, Kean RB, Dickson GM, Dietzschold B, Hooper DC. Neonatal Borna disease virus infection in the rat causes a loss of Purkinje cells in the cerebellum. J Neurovirol . 1999 Apr 1 ; 5(2):181-9. Abstract

Lancaster K, Dietz DM, Moran TH, Pletnikov MV. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behav Brain Res . 2007 Jan 10 ; 176(1):141-8. Abstract


August 20, 2014
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