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Animal Model:
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Rat Maternal Malnutrition
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Preparation Type:
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Developmental Preparations
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DA-related behavior:
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Enhanced amphetamine- but not MK-801-induced locomotion and
apomorphine-induced stereotopy; (females only with
post-pubertal onset)
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Gating:
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Disrupted PPI (females only with post-pubertal onset)
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Molecular/morphological signature:
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Increases in NMDA receptor binding (sex- and
region-specific); increased DA receptor binding and
decreased DA transporter binding in striatum (females only)
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Citations:
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Palmer AA, Printz DJ, Butler PD, Dulawa SC, Printz MP.
Prenatal protein deprivation in rats induces changes in
prepulse inhibition and NMDA receptor binding. Brain Res .
2004 Jan 23 ; 996(2):193-201. Abstract
Palmer AA, Brown AS, Keegan D, Siska LD, Susser E,
Rotrosen J, Butler PD. Prenatal protein deprivation alters
dopamine-mediated behaviors and dopaminergic and
glutamatergic receptor binding. Brain Res . 2008 Oct 27 ;
1237():62-74. Abstract
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