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Animal Models

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Animal Model: Rat Isolation Rearing
Preparation Type: Developmental Preparations
DA-related behavior: Enhanced amphetamine-induced locomotion and DA release (strain-dependent)
Gating: Disrupted PPI (strain-dependent)
Cognitive behavior: Performance on Morris water maze and T-maze appears normal Impaired novel object recognition, attentional set-shifting, and performance on Morris water maze
Social behavior: Increased social interaction and aggression (males); impaired social recognition
Molecular/morphological signature: Reduced PFC volume (neuron # unchanged) and GAT-1 expression; altered accumbal protein expression (some correlated with PPI deficits); reduced accumbal dendritic length and spine density; altered NMDA receptor mRNA and protein expression in the hippocampus and prefrontal cortex; enhanced amplitudes of hippocampal voltage-dependent transient outward K+ currents
Response to APD: Raclopride reversed PPI deficit
Citations: Geyer MA, Wilkinson LS, Humby T, Robbins TW. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry . 1993 Sep 15 ; 34(6):361-72. Abstract

Varty GB, Geyer MA. Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats. Behav Neurosci . 1998 Dec 1 ; 112(6):1450-7. Abstract

Weiss IC, Di Iorio L, Feldon J, Domeney AM. Strain differences in the isolation-induced effects on prepulse inhibition of the acoustic startle response and on locomotor activity. Behav Neurosci . 2000 Apr 1 ; 114(2):364-73. Abstract

Heidbreder CA, Weiss IC, Domeney AM, Pryce C, Homberg J, Hedou G, Feldon J, Moran MC, Nelson P. Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience . 2000 Jan 1 ; 100(4):749-68. Abstract

Day-Wilson KM, Jones DN, Southam E, Cilia J, Totterdell S. Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle. Neuroscience . 2006 Sep 1 ; 141(3):1113-21. Abstract

Ferdman N, Murmu RP, Bock J, Braun K, Leshem M. Weaning age, social isolation, and gender, interact to determine adult explorative and social behavior, and dendritic and spine morphology in prefrontal cortex of rats. Behav Brain Res . 2007 Jun 18 ; 180(2):174-82. Abstract

Roncada P, Bortolato M, Frau R, Saba P, Flore G, Soggiu A, Pisanu S, Amoresano A, Carpentieri A, Devoto P. Gating deficits in isolation-reared rats are correlated with alterations in protein expression in nucleus accumbens. J Neurochem . 2009 Feb 1 ; 108(3):611-20. Abstract

McLean S, Grayson B, Harris M, Protheroe C, Bate S, Woolley M, Neill J. Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats. J Psychopharmacol . 2008 Nov 21. Abstract

Bloomfield C, French SJ, Jones DN, Reavill C, Southam E, Cilia J, Totterdell S. Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats. Synapse . 2008 Aug 1 ; 62(8):628-31. Abstract

Fone KC, Porkess MV. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev . 2008 Aug 1 ; 32(6):1087-102. Abstract

Alquicer G, Morales-Medina JC, Quirion R, Flores G. Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis. J Chem Neuroanat . 2008 Mar 1 ; 35(2):179-87. Abstract

July 25, 2014
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