Animal Model:	Rat Isolation Rearing
Preparation Type:	Developmental Preparations
DA-related behavior:	Enhanced amphetamine-induced locomotion and DA release (strain-dependent)
Gating:	Disrupted PPI (strain-dependent)
Cognitive behavior:	Performance on Morris water maze and T-maze appears normal Impaired novel object recognition, attentional set-shifting, and performance on Morris water maze
Social behavior:	Increased social interaction and aggression (males); impaired social recognition
Molecular/morphological signature:	Reduced PFC volume (neuron # unchanged) and GAT-1 expression; altered accumbal protein expression (some correlated with PPI deficits); reduced accumbal dendritic length and spine density; altered NMDA receptor mRNA and protein expression in the hippocampus and prefrontal cortex; enhanced amplitudes of hippocampal voltage-dependent transient outward K+ currents
Response to APD:	Raclopride reversed PPI deficit
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