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product or therapy. ALL medications and supplements
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due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Rat 24 hour Maternal Deprivation on Post-natal Day 9
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Preparation Type:
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Developmental Preparations
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Gating:
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Disrupted PPI, Effect develops after puberty.
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Molecular/morphological signature:
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Males only: neuronal degeneration and increased GFAP+ cells
in cerebellum; neuronal degeneration and increased
astrocytes in hippocampus
Both sexes: altered cannabinoid receptor expression in
hippocampus; increased plasma glucocorticoid levels;
increased levels of 5-
HT in the prefrontal cortex, hippocampus, and striatum (some
changes sex dependent); increased levels of DA in the
prefrontal cortex and striatum
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Response to APD:
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Haloperidol reverses PPI deficit.
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Citations:
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Ellenbroek BA, van den Kroonenberg PT, Cools AR. The effects
of an early stressful life event on sensorimotor gating in
adult rats. Schizophr Res . 1998 Apr 10 ; 30(3):251-60. Abstract
López-Gallardo M, Llorente R, Llorente-Berzal A,
Marco EM, Prada C, Di Marzo V, Viveros MP. Neuronal and
glial alterations in the cerebellar cortex of maternally
deprived rats: gender differences and modulatory effects of
two inhibitors of endocannabinoid inactivation. Dev
Neurobiol . 2008 Oct 1 ; 68(12):1429-40. Abstract
Llorente R, Llorente-Berzal A, Petrosino S, Marco
EM, Guaza C, Prada C, López-Gallardo M, Di Marzo V, Viveros
MP. Gender-dependent cellular and biochemical effects of
maternal deprivation on the hippocampus of neonatal rats: A
possible role for the endocannabinoid system. Dev Neurobiol
. 2008 Sep 15 ; 68(11):1334-47. Abstract
Llorente R, Gallardo ML, Berzal AL, Prada C,
Garcia-Segura LM, Viveros MP. Early maternal deprivation in
rats induces gender-dependent effects on developing
hippocampal and cerebellar cells. Int J Dev Neurosci . 2009
May ; 27(3):233-41. Abstract
Llorente R, O'Shea E, Gutierrez-Lopez MD,
Llorente-Berzal A, Colado MI, Viveros MP. Sex-dependent
maternal deprivation effects on brain monoamine content in
adolescent rats. Neurosci Lett . 2010 Jul 26 ; 479(2):112-7.
Abstract
Suárez J, Llorente R, Romero-Zerbo SY, Mateos B,
Bermúdez-Silva FJ, de Fonseca FR, Viveros MP. Early maternal
deprivation induces gender-dependent changes on the
expression of hippocampal CB(1) and CB(2) cannabinoid
receptors of neonatal rats. Hippocampus . 2008 Dec 29. Abstract
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