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Animal Models

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Animal Model: Neonatal Amygdalar Lesion
Preparation Type: Lesion Preparations
DA-related behavior: Enhanced amphetamine or apomorphine induced locomotion; increased novelty induced locomotor activity
Gating: Increased acoustic startle response but impair PPI on animals lesioned on PND 7 but not PND 21; abnormally persistent latent inhibition
Cognitive behavior: Impaired place navigation and spatial ability (not found by all studies); impaired spatial alternation and food hoarding
Social behavior: Social behaviors diminished in animals lesioned on PND 7 but not 21 but ventral HPC lesions did not affect social behavior
Molecular/morphological signature: Increased lateral ventricular volume; reduced density of D1- and D2-like but not D3-like receptors and increased DA turnover in mesolimbic but not striatal regions; decreased spine density in the prefrontal cortex and nucleus accumbens
Citations: Daenen EW, Wolterink G, Gerrits MA, van Ree JM. The effects of neonatal lesions in the amygdala or ventral hippocampus on social behaviour later in life. Behav Brain Res. 2002 Nov 15 ; 136(2):571-82. Abstract

Daenen EW, Wolterink G, Van Der Heyden JA, Kruse CG, van Ree JM. Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia. Eur Neuropsychopharmacol. 2003 May 1 ; 13(3):187-97. Abstract

Hanlon FM, Sutherland RJ. Changes in adult brain and behavior caused by neonatal limbic damage: implications for the etiology of schizophrenia. Behav Brain Res. 2000 Jan 1 ; 107(1-2):71-83. Abstract

Weiner I. The 'two-headed' latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment. Psychopharmacology (Berl). 2003 Sep 1 ; 169(3-4):257-97. Abstract

Diergaarde L, Gerrits MA, Brouwers JP, van Ree JM. Early amygdala damage disrupts performance on medial prefrontal cortex-related tasks but spares spatial learning and memory in the rat. Neuroscience. 2005 Jan 1 ; 130(3):581-90. Abstract

Bouwmeester H, Gerrits MA, Roozemond JG, Snapper J, Ronken E, Kruse CG, Westenberg HG, van Ree JM. Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats. Int J Neuropsychopharmacol. 2007 Dec 1 ; 10(6):727-39. Abstract

Solis O, Vázquez-Roque RA, Camacho-Abrego I, Gamboa C, de la Cruz F, Zamudio S, Flores G. Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion. Synapse . 2009 Dec ; 63(12):1143-53. Abstract

Vázquez-Roque RA, Solis O, Camacho-Abrego I, Rodríguez-Moreno A, Cruz Fde L, Zamudio S, Flores G. Dendritic morphology of neurons in prefrontal cortex and ventral hippocampus of rats with neonatal amygdala lesion. Synapse . 2012 May ; 66(5):373-82. Abstract

July 25, 2016
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Check out our upcoming webinar, Studying Psychosis in 22q11 Deletion Syndrome, Thursday, July 28, 2016, 1-2:30 p.m. EDT.

See our recent webinar, The Baby and the Bathwater: Signal and Noise in Psychiatric Neuroimaging.
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