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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Alpha-CaMKII KO, Heterozygous
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Increased locomotor.
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Cognitive behavior:
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Deficits in working memory.
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Social behavior:
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Increased aggressive behavior.
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Molecular/morphological signature:
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Impaired neuronal development in the dentate gyrus.
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Citations:
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Yamasaki N, Maekawa M, Kobayashi K, Kajii Y, Maeda J, Soma
M, Takao K, Tanda K, Ohira K, Toyama K, Kanzaki K, Fukunaga
K, Sudo Y, Ichinose H, Ikeda M, Iwata N, Ozaki N, Suzuki H,
Higuchi M, Suhara T, Yuasa S, Miyakawa T. Alpha-CaMKII
deficiency causes immature dentate gyrus, a novel candidate
endophenotype of psychiatric disorders. Mol Brain. 2008 Jan
1 ; 1(1):6. Abstract
Chen C, Rainnie DG, Greene RW, Tonegawa S. Abnormal
fear response and aggressive behavior in mutant mice
deficient for alpha-calcium-calmodulin kinase II. Science.
1994 Oct 14 ; 266(5183):291-4. Abstract
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