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Animal Models

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Animal Model: Mouse Prenatal Immune Challenge: Human Influenza Virus
Preparation Type: Developmental Preparations
DA-related behavior: Decreased open field exploration
Gating: Impaired PPI
Social behavior: Impaired social interaction
Molecular/morphological signature: Reduced reelin expression in cortex layer 1; increased pyramidal cell density; cortical and callosal atrophy; reduced 5-HT levels in cerebellum atrophy; altered expression of myelination genes in the cerebellum; reduced 5-HT levels in cerebellum; increased 5-HT2A receptor expression in frontal cortex
Response to APD: Clozapine and chlorpromazine increase PPI – hyper-reversal of PPI deficit
Citations: Fatemi SH, Emamian ES, Kist D, Sidwell RW, Nakajima K, Akhter P, Shier A, Sheikh S, Bailey K. Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice. Mol Psychiatry. 1999 Mar 1; 4(2):145-54. Abstract

Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci . 2003 Jan 1 ; 23(1):297-302. Abstract

Fatemi SH, Pearce DA, Brooks AI, Sidwell RW. Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism. Synapse. 2005 Aug 1; 57(2):91-9. Abstract

Fatemi SH, Reutiman TJ, Folsom TD, Huang H, Oishi K, Mori S, Smee DF, Pearce DA, Winter C, Sohr R, Juckel G. Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders. Schizophr Res . 2008 Feb 1 ; 99(1-3):56-70. Abstract

Winter C, Reutiman TJ, Folsom TD, Sohr R, Wolf RJ, Juckel G, Fatemi SH. Dopamine and serotonin levels following prenatal viral infection in mouse--implications for psychiatric disorders such as schizophrenia and autism. Eur Neuropsychopharmacol. 2008 Oct 1; 18(10):712-6. Abstract

Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci. 2011;31(5):1863-72. Abstract


August 20, 2014
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