Schizophrenia Research Forum: Animal Models

Name	DA-related behavior	Gating	Cognitive behavior	Social behavior	Molecular morphological signature	Response to APD
mhDISC1 and polyI:C exposure	Increased activity in periphery of open field	No PPI deficit	No interaction effects on novel object recognition; sptial working memory in Y maze, or spatial learning in water maze	Lack of preference for sniffing mouse vs inanimate object; normal social novelty preference	PolyI:C exposure on gestation day 9; genotype affected cytokine upregulation in response to immune challenge; reduced hippocampal dendritic spine density; attenuated corticosterone response to restraint stress
Complexin II KO and parietal neurotrauma	No interaction effect on open field behavior	No interaction effect on PPI; increase in startle amplitude	Spatial memory deficit	No interaction effect on social interaction	Reduced hippocampal volume
COMT KO and chronic THC exposure	Increased hyperactivity in open field in males		No interaction effect on object recognition; increased spatial working memory impairment	No interaction effects on social interaction or social novelty preference
GAD67 heterozygous KO and prenatal stress					Increased fetal corticosterone level and decreased fetal weight
Nurr1 heterozygous KO and polyI:C exposure	Hyperactive in open field	Increased PPI deficit	Impaired attentional shifting; no interaction effect on spatial working memory		Decreased accumbal D2 receptors; decreased PFC tyrosine hydroxylase expression; increased PFC COMT expression
PACAP KO mice and early life social isolation	Hyperactive in open field	No interaction effect on PPI or startle amplitude		Increased aggression
Snap-25 heterozygous KO/bdr and prenatal stress	No interaction on open field activity	PNS/Bdr mice had increased deficit in PPI	No interaction effect on short-term memory in Y maze task; no effect on novel object recognition	Decreased social interaction and impaired social novelty preference in PNS/Bdr mice		Clozapine improved PPI deficit in PDS/Bdr
DN-DISC1 and PolyI:C exposure	Hypersensitive to MK-801		Impaired object recognition; impaired fear conditioning	Decreased social interaction; impaired social recognition	PolyI :C exposure on postnatal days 2-6; Decreased GABAergic interneurons in mPFC	Clozapine normalized sensitivity to MK-801 as well as cognitive impairment; did not improve social deficits