Schizophrenia Research Forum: Animal Models
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Animal Models:Lesion
Name DA-related behavior Gating Cognitive behavior Social behavior Molecular and/or Morphological Signature Response to APD
Neonatal Amygdalar Lesion Enhanced amphetamine or apomorphine induced locomotion; increased novelty induced locomotor activity Increased acoustic startle response but impair PPI on animals lesioned on PND 7 but not PND 21; abnormally persistent latent inhibition Impaired place navigation and spatial ability (not found by all studies); impaired spatial alternation and food hoarding Social behaviors diminished in animals lesioned on PND 7 but not 21 but ventral HPC lesions did not affect social behavior Increased lateral ventricular volume; reduced density of D1- and D2-like but not D3-like receptors and increased DA turnover in mesolimbic but not striatal regions; decreased spine density in the prefrontal cortex and nucleus accumbens  
Neonatal NGF-Induced Frontal Cortex Lesion Hyperactivity     Social interaction deficit    
Neonatal Ventral Hippocampal Lesion Enhanced locomotor responses to amphetamine with post-pubertal onset; enhanced meth-amphetamine self-administration Disrupted PPI; prolonged N40 latency Various impairments in learning and memory (including set-shifting and spatial working memory) Impaired social behavior Reduced presynaptic protein and growth factor expression, reduced NMDA receptor expression, impaired DA receptor expression in frontal cortex; impaired maturation of PFC; brain region- and age-specific changes in GABAA receptor expression; reduced PFC spine density; enhanced sensitivity to nicotine; increased prefrontal DA output Locomotor responses blocked by APD, social impairments blocked by clozapine but not haloperidol; clozapine reversed enhanced novelty-induced locomotor activity and rescued neuronal atrophy in the prefrontal cortex and nucleus accumbens