Schizophrenia Research Forum: Animal Models

Amar S, Jones BC, Nadri C, Kozlovsky N, Belmaker RH, Agam G. Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice. Genes Brain Behav . 2004 Jun 1 ; 3(3):178-80. Abstract

Ballmaier M, Zoli M, Leo G, Agnati LF, Spano P. Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia. Eur J Neurosci . 2002 Apr 1 ; 15(7):1197-205. Abstract

Costa E, Davis J, Pesold C, Tueting P, Guidotti A. The heterozygote reeler mouse as a model for the development of a new generation of antipsychotics. Curr Opin Pharmacol . 2002 Feb 1 ; 2(1):56-62. Abstract

Podhorna J, Didriksen M. The heterozygous reeler mouse: behavioural phenotype. Behav Brain Res . 2004 Aug 12 ; 153(1):43-54. Abstract

Bannerman DM, Deacon RM, Brady S, Bruce A, Sprengel R, Seeburg PH, Rawlins JN. A comparison of GluR-A-deficient and wild-type mice on a test battery assessing sensorimotor, affective, and cognitive behaviors. Behav Neurosci . 2004 Jun 1 ; 118(3):643-7. Abstract

Wiedholz LM, Owens WA, Horton RE, Feyder M, Karlsson RM, Hefner K, Sprengel R, Celikel T, Daws LC, Holmes A. Mice lacking the AMPA GluR1 receptor exhibit striatal hyperdopaminergia and 'schizophrenia-related' behaviors. Mol Psychiatry . 2008 Jun 1 ; 13(6):631-40. Abstract

Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell . 2005 Jul 29 ; 122(2):261-73. Abstract

Beglopoulos V, Montag-Sallaz M, Rohlmann A, Piechotta K, Ahmad M, Montag D, Missler M. Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol . 2005 Aug 1 ; 25(16):7278-88. Abstract

Behan AT, van den Hove DL, Mueller L, Jetten MJ, Steinbusch HW, Cotter DR, Prickaerts J. Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress. Eur Neuropsychopharmacol . 2011 Jan ; 21(1):71-9. Abstract

Pascual R, Ebner D, Araneda R, Urqueta MJ, Bustamante C. Maternal stress induces long-lasting Purkinje cell developmental impairments in mouse offspring. Eur J Pediatr . 2010 Dec ; 169(12):1517-22. Abstract

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A. Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology . 2012 Apr 28. Abstract

Matrisciano F, Tueting P, Maccari S, Nicoletti F, Guidotti A. Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology . 2012 Mar ; 37(4):929-38. Abstract

Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology . 2013 Apr ; 38(4):509-21. Abstract

Berretta S, Munno DW, Benes FM. Amygdalar activation alters the hippocampal GABA system: 'partial' modelling for postmortem changes in schizophrenia. J Comp Neurol . 2001 Mar 5 ; 431(2):129-38. Abstract

Gisabella B, Bolshakov VY, Benes FM. Regulation of synaptic plasticity in a schizophrenia model. Proc Natl Acad Sci U S A . 2005 Sep 13 ; 102(37):13301-6. Abstract

Berretta S, Benes FM. A rat model for neural circuitry abnormalities in schizophrenia. Nat Protoc . 2006 Jan 1 ; 1(2):833-9. Abstract

Bielsky IF, Hu SB, Ren X, Terwilliger EF, Young LJ. The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Neuron . 2005 Aug 18 ; 47(4):503-13. Abstract

Boksa P. Animal models of obstetric complications in relation to schizophrenia. Brain Res Brain Res Rev . 2004 Apr 1 ; 45(1):1-17. Abstract

Hoeger H, Engelmann M, Bernert G, Seidl R, Bubna-Littitz H, Mosgoeller W, Lubec B, Lubec G. Long term neurological and behavioral effects of graded perinatal asphyxia in the rat. Life Sci . 2000 Jan 1 ; 66(10):947-62. Abstract

Wakuda T, Matsuzaki H, Suzuki K, Iwata Y, Shinmura C, Suda S, Iwata K, Yamamoto S, Sugihara G, Tsuchiya KJ, Ueki T, Nakamura K, Nakahara D, Takei N, Mori N. Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood. PLoS ONE . 2008 Jan 1 ; 3(11):e3648. Abstract

Juárez I, Gratton A, Flores G. Ontogeny of altered dendritic morphology in the rat prefrontal cortex, hippocampus, and nucleus accumbens following Cesarean delivery and birth anoxia. J Comp Neurol . 2008 Apr 10 ; 507(5):1734-47. Abstract

Fendt M, Lex A, Falkai P, Henn FA, Schmitt A. Behavioural alterations in rats following neonatal hypoxia and effects of clozapine: implications for schizophrenia. Pharmacopsychiatry . 2008 Jul ; 41(4):138-45. Abstract

Sommer JU, Schmitt A, Heck M, Schaeffer EL, Fendt M, Zink M, Nieselt K, Symons S, Petroianu G, Lex A, Herrera-Marschitz M, Spanagel R, Falkai P, Gebicke-Haerter PJ. Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia. Eur Arch Psychiatry Clin Neurosci . 2010 Nov ; 260 Suppl 2():S81-9. Abstract

Schaeffer EL, Kühn F, Schmitt A, Gattaz WF, Gruber O, Schneider-Axmann T, Falkai P, Schmitt A. Increased cell proliferation in the rat anterior cingulate cortex following neonatal hypoxia: relevance to schizophrenia. J Neural Transm . 2013 Jan ; 120(1):187-95. Abstract

Borrell J, Vela JM, Arévalo-Martin A, Molina-Holgado E, Guaza C. Prenatal immune challenge disrupts sensorimotor gating in adult rats. Implications for the etiopathogenesis of schizophrenia. Neuropsychopharmacology . 2002 Feb 1 ; 26(2):204-15. Abstract

Baharnoori M, Brake WG, Srivastava LK. Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats. Schizophr Res . 2009 Jan 1 ; 107(1):99-109. Abstract

Fortier ME, Joober R, Luheshi GN, Boksa P. Maternal exposure to bacterial endotoxin during pregnancy enhances amphetamine-induced locomotion and startle responses in adult rat offspring. J Psychiatr Res . 2004 May-Jun ; 38(3):335-45. Abstract

Fortier ME, Luheshi GN, Boksa P. Effects of prenatal infection on prepulse inhibition in the rat depend on the nature of the infectious agent and the stage of pregnancy. Behav Brain Res . 2007 Aug 6 ; 181(2):270-7. Abstract

Hava G, Vered L, Yael M, Mordechai H, Mahoud H. Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy. Dev Psychobiol . 2006 Mar 1 ; 48(2):162-8. Abstract

Romero E, Ali C, Molina-Holgado E, Castellano B, Guaza C, Borrell J. Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics. Neuropsychopharmacology . 2007 Aug 1 ; 32(8):1791-804. Abstract

Romero E, Guaza C, Castellano B, Borrell J. Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: implications for the etiopathology of schizophrenia. Mol Psychiatry . 2008 Apr 15. Abstract

Jenkins TA, Harte MK, Stenson G, Reynolds GP. Neonatal lipopolysaccharide induces pathological changes in parvalbumin immunoreactivity in the hippocampus of the rat. Behav Brain Res . 2009 Dec 28 ; 205(2):355-9. Abstract

Oskvig DB, Elkahloun AG, Johnson KR, Phillips TM, Herkenham M. Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response. Brain Behav Immun . 2012 May ; 26(4):623-34. Abstract

Brody SA, Conquet F, Geyer MA. Disruption of prepulse inhibition in mice lacking mGluR1. Eur J Neurosci . 2003 Dec 1 ; 18(12):3361-6. Abstract

Daenen EW, Wolterink G, Gerrits MA, van Ree JM. The effects of neonatal lesions in the amygdala or ventral hippocampus on social behaviour later in life. Behav Brain Res. 2002 Nov 15 ; 136(2):571-82. Abstract

Daenen EW, Wolterink G, Van Der Heyden JA, Kruse CG, van Ree JM. Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia. Eur Neuropsychopharmacol. 2003 May 1 ; 13(3):187-97. Abstract

Hanlon FM, Sutherland RJ. Changes in adult brain and behavior caused by neonatal limbic damage: implications for the etiology of schizophrenia. Behav Brain Res. 2000 Jan 1 ; 107(1-2):71-83. Abstract

Weiner I. The 'two-headed' latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment. Psychopharmacology (Berl). 2003 Sep 1 ; 169(3-4):257-97. Abstract

Diergaarde L, Gerrits MA, Brouwers JP, van Ree JM. Early amygdala damage disrupts performance on medial prefrontal cortex-related tasks but spares spatial learning and memory in the rat. Neuroscience. 2005 Jan 1 ; 130(3):581-90. Abstract

Bouwmeester H, Gerrits MA, Roozemond JG, Snapper J, Ronken E, Kruse CG, Westenberg HG, van Ree JM. Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats. Int J Neuropsychopharmacol. 2007 Dec 1 ; 10(6):727-39. Abstract

Solis O, Vázquez-Roque RA, Camacho-Abrego I, Gamboa C, de la Cruz F, Zamudio S, Flores G. Decreased dendritic spine density of neurons of the prefrontal cortex and nucleus accumbens and enhanced amphetamine sensitivity in postpubertal rats after a neonatal amygdala lesion. Synapse . 2009 Dec ; 63(12):1143-53. Abstract

Vázquez-Roque RA, Solis O, Camacho-Abrego I, Rodríguez-Moreno A, Cruz Fde L, Zamudio S, Flores G. Dendritic morphology of neurons in prefrontal cortex and ventral hippocampus of rats with neonatal amygdala lesion. Synapse . 2012 May ; 66(5):373-82. Abstract

Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proc Natl Acad Sci U S A . 2008 Jul 15 ; 105(28):9775-80. Abstract

Ellenbroek BA, Cools AR. Apomorphine susceptibility and animal models for psychopathology: genes and environment. Behav Genet . 2002 Sep 1 ; 32(5):349-61. Abstract

Ellenbroek BA, van den Kroonenberg PT, Cools AR. The effects of an early stressful life event on sensorimotor gating in adult rats. Schizophr Res . 1998 Apr 10 ; 30(3):251-60. Abstract

López-Gallardo M, Llorente R, Llorente-Berzal A, Marco EM, Prada C, Di Marzo V, Viveros MP. Neuronal and glial alterations in the cerebellar cortex of maternally deprived rats: gender differences and modulatory effects of two inhibitors of endocannabinoid inactivation. Dev Neurobiol . 2008 Oct 1 ; 68(12):1429-40. Abstract

Llorente R, Llorente-Berzal A, Petrosino S, Marco EM, Guaza C, Prada C, López-Gallardo M, Di Marzo V, Viveros MP. Gender-dependent cellular and biochemical effects of maternal deprivation on the hippocampus of neonatal rats: A possible role for the endocannabinoid system. Dev Neurobiol . 2008 Sep 15 ; 68(11):1334-47. Abstract

Llorente R, Gallardo ML, Berzal AL, Prada C, Garcia-Segura LM, Viveros MP. Early maternal deprivation in rats induces gender-dependent effects on developing hippocampal and cerebellar cells. Int J Dev Neurosci . 2009 May ; 27(3):233-41. Abstract

Llorente R, O'Shea E, Gutierrez-Lopez MD, Llorente-Berzal A, Colado MI, Viveros MP. Sex-dependent maternal deprivation effects on brain monoamine content in adolescent rats. Neurosci Lett . 2010 Jul 26 ; 479(2):112-7. Abstract

Suárez J, Llorente R, Romero-Zerbo SY, Mateos B, Bermúdez-Silva FJ, de Fonseca FR, Viveros MP. Early maternal deprivation induces gender-dependent changes on the expression of hippocampal CB(1) and CB(2) cannabinoid receptors of neonatal rats. Hippocampus . 2008 Dec 29. Abstract

Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet . 2004 Feb ; 36(2):131-7. Abstract

Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, Diaz-Arrastia R, Brunskill EW, Potter SS, McKnight SL. Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci U S A . 2004 Sep 14 ; 101(37):13648-53. Abstract

Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC, Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ, McKnight SL. The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. Proc Natl Acad Sci U S A . 2005 Sep 27 ; 102(39):14052-7. Abstract

Fatemi SH, Emamian ES, Kist D, Sidwell RW, Nakajima K, Akhter P, Shier A, Sheikh S, Bailey K. Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice. Mol Psychiatry. 1999 Mar 1; 4(2):145-54. Abstract

Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci . 2003 Jan 1 ; 23(1):297-302. Abstract

Fatemi SH, Pearce DA, Brooks AI, Sidwell RW. Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism. Synapse. 2005 Aug 1; 57(2):91-9. Abstract

Fatemi SH, Reutiman TJ, Folsom TD, Huang H, Oishi K, Mori S, Smee DF, Pearce DA, Winter C, Sohr R, Juckel G. Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders. Schizophr Res . 2008 Feb 1 ; 99(1-3):56-70. Abstract

Winter C, Reutiman TJ, Folsom TD, Sohr R, Wolf RJ, Juckel G, Fatemi SH. Dopamine and serotonin levels following prenatal viral infection in mouse--implications for psychiatric disorders such as schizophrenia and autism. Eur Neuropsychopharmacol. 2008 Oct 1; 18(10):712-6. Abstract

Moreno JL, Kurita M, Holloway T, López J, Cadagan R, Martínez-Sobrido L, García-Sastre A, González-Maeso J. Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci. 2011;31(5):1863-72. Abstract

Ferguson JN, Aldag JM, Insel TR, Young LJ. Oxytocin in the medial amygdala is essential for social recognition in the mouse. J Neurosci . 2001 Oct 15 ; 21(20):8278-85. Abstract

Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM, Young LJ, Nishimori K. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci U S A . 2005 Nov 1 ; 102(44):16096-101. Abstract

Fradley RL, O'Meara GF, Newman RJ, Andrieux A, Job D, Reynolds DS. STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating. Behav Brain Res . 2005 Sep 8 ; 163(2):257-64. Abstract

Geyer MA, Wilkinson LS, Humby T, Robbins TW. Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry . 1993 Sep 15 ; 34(6):361-72. Abstract

Varty GB, Geyer MA. Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats. Behav Neurosci . 1998 Dec 1 ; 112(6):1450-7. Abstract

Weiss IC, Di Iorio L, Feldon J, Domeney AM. Strain differences in the isolation-induced effects on prepulse inhibition of the acoustic startle response and on locomotor activity. Behav Neurosci . 2000 Apr 1 ; 114(2):364-73. Abstract

Heidbreder CA, Weiss IC, Domeney AM, Pryce C, Homberg J, Hedou G, Feldon J, Moran MC, Nelson P. Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome. Neuroscience . 2000 Jan 1 ; 100(4):749-68. Abstract

Day-Wilson KM, Jones DN, Southam E, Cilia J, Totterdell S. Medial prefrontal cortex volume loss in rats with isolation rearing-induced deficits in prepulse inhibition of acoustic startle. Neuroscience . 2006 Sep 1 ; 141(3):1113-21. Abstract

Ferdman N, Murmu RP, Bock J, Braun K, Leshem M. Weaning age, social isolation, and gender, interact to determine adult explorative and social behavior, and dendritic and spine morphology in prefrontal cortex of rats. Behav Brain Res . 2007 Jun 18 ; 180(2):174-82. Abstract

Roncada P, Bortolato M, Frau R, Saba P, Flore G, Soggiu A, Pisanu S, Amoresano A, Carpentieri A, Devoto P. Gating deficits in isolation-reared rats are correlated with alterations in protein expression in nucleus accumbens. J Neurochem . 2009 Feb 1 ; 108(3):611-20. Abstract

McLean S, Grayson B, Harris M, Protheroe C, Bate S, Woolley M, Neill J. Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats. J Psychopharmacol . 2008 Nov 21. Abstract

Bloomfield C, French SJ, Jones DN, Reavill C, Southam E, Cilia J, Totterdell S. Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats. Synapse . 2008 Aug 1 ; 62(8):628-31. Abstract

Fone KC, Porkess MV. Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev . 2008 Aug 1 ; 32(6):1087-102. Abstract

Alquicer G, Morales-Medina JC, Quirion R, Flores G. Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis. J Chem Neuroanat . 2008 Mar 1 ; 35(2):179-87. Abstract

Glynn D, Drew CJ, Reim K, Brose N, Morton AJ. Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits. Hum Mol Genet . 2005 Aug 15 ; 14(16):2369-85. Abstract

Gogos JA, Morgan M, Luine V, Santha M, Ogawa S, Pfaff D, Karayiorgou M. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A . 1998 Aug 18 ; 95(17):9991-6. Abstract

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Gogos JA, Santha M, Takacs Z, Beck KD, Luine V, Lucas LR, Nadler JV, Karayiorgou M. The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. Nat Genet . 1999 Apr 1 ; 21(4):434-9. Abstract

Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H, Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P, Siegelbaum SA, Karayiorgou M, Gogos JA. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nat Neurosci . 2005 Nov 1 ; 8(11):1586-94. Abstract

Gourevitch R, Rocher C, Le Pen G, Krebs MO, Jay TM. Working memory deficits in adult rats after prenatal disruption of neurogenesis. Behav Pharmacol . 2004 Jul 1 ; 15(4):287-92. Abstract

Flagstad P, Mørk A, Glenthøj BY, van Beek J, Michael-Titus AT, Didriksen M. Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology . 2004 Nov 1 ; 29(11):2052-64. Abstract

Elmer GI, Sydnor J, Guard H, Hercher E, Vogel MW. Altered prepulse inhibition in rats treated prenatally with the antimitotic Ara-C: an animal model for sensorimotor gating deficits in schizophrenia. Psychopharmacology (Berl) . 2004 Jul 1 ; 174(2):177-89. Abstract

Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA. A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol Psychiatry . 2006 Aug 1 ; 60(3):253-64. Abstract

Featherstone RE, Rizos Z, Nobrega JN, Kapur S, Fletcher PJ. Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia. Neuropsychopharmacology . 2007 Feb 1 ; 32(2):483-92. Abstract

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Chin CL, Curzon P, Schwartz AJ, O'Connor EM, Rueter LE, Fox GB, Day M, Basso AM. Structural abnormalities revealed by magnetic resonance imaging in rats prenatally exposed to methylazoxymethanol acetate parallel cerebral pathology in schizophrenia. Synapse . 2011 May ; 65(5):393-403. Abstract

Hradetzky E, Sanderson TM, Tsang TM, Sherwood JL, Fitzjohn SM, Lakics V, Malik N, Schoeffmann S, O'Neill MJ, Cheng TM, Harris LW, Rahmoune H, Guest PC, Sher E, Collingridge GL, Holmes E, Tricklebank MD, Bahn S. The methylazoxymethanol acetate (MAM-E17) rat model: molecular and functional effects in the hippocampus. Neuropsychopharmacology . 2012 Jan ; 37(2):364-77. Abstract

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Mandyam CD, Crawford EF, Eisch AJ, Rivier CL, Richardson HN. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev Neurobiol . 2008 Apr ; 68(5):575-89. Abstract

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Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K, Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T, Ozaki N, Kaibuchi K, Iwata N. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet . 2008 Oct 15 ; 17(20):3212-22. Abstract

Kesby JP, Burne TH, McGrath JJ, Eyles DW. Developmental vitamin D deficiency alters MK 801-induced hyperlocomotion in the adult rat: An animal model of schizophrenia. Biol Psychiatry . 2006 Sep 15 ; 60(6):591-6. Abstract

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Eyles D, Almeras L, Benech P, Patatian A, Mackay-Sim A, McGrath J, Féron F. Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. J Steroid Biochem Mol Biol . 2007 Mar 1 ; 103(3-5):538-45. Abstract

Féron F, Burne TH, Brown J, Smith E, McGrath JJ, Mackay-Sim A, Eyles DW. Developmental Vitamin D3 deficiency alters the adult rat brain. Brain Res Bull . 2005 Mar 15 ; 65(2):141-8. Abstract

Almeras L, Eyles D, Benech P, Laffite D, Villard C, Patatian A, Boucraut J, Mackay-Sim A, McGrath J, Féron F. Developmental vitamin D deficiency alters brain protein expression in the adult rat: implications for neuropsychiatric disorders. Proteomics . 2007 Mar 1 ; 7(5):769-80. Abstract

McGrath J, Iwazaki T, Eyles D, Burne T, Cui X, Ko P, Matsumoto I. Protein expression in the nucleus accumbens of rats exposed to developmental vitamin D deficiency. PLoS ONE . 2008 Jan 1 ; 3(6):e2383. Abstract

Harms LR, Eyles DW, McGrath JJ, Mackay-Sim A, Burne TH. Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice. Behav Brain Res . 2008 Mar 5 ; 187(2):343-50. Abstract

Keilhoff G, Grecksch G, Becker A. Haloperidol normalized prenatal vitamin D depletion-induced reduction of hippocampal cell proliferation in adult rats. Neurosci Lett . 2010 May 31 ; 476(2):94-8. Abstract

Kinney GG, Burno M, Campbell UC, Hernandez LM, Rodriguez D, Bristow LJ, Conn PJ. Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther . 2003 Jul 1 ; 306(1):116-23. Abstract

Brody SA, Dulawa SC, Conquet F, Geyer MA. Assessment of a prepulse inhibition deficit in a mutant mouse lacking mGlu5 receptors. Mol Psychiatry . 2004 Jan 1 ; 9(1):35-41. Abstract

Kinnunen AK, Koenig JI, Bilbe G. Repeated variable prenatal stress alters pre- and postsynaptic gene expression in the rat frontal pole. J Neurochem . 2003 Aug 1 ; 86(3):736-48. Abstract

Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B, Hercher E, Brady DL. Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res . 2005 Jan 30 ; 156(2):251-61. Abstract

Mandyam CD, Crawford EF, Eisch AJ, Rivier CL, Richardson HN. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev. Neurobiol. 68 (5): 575-589. Abstract

Markham JA, Taylor AR, Taylor SB, Bell DB, Koenig JI. Characterization of the cognitive impairments induced by prenatal exposure to stress in the rat. Front Behav Neurosci. 2010;4:173. Abstract

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