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Burmeister M. on WHAT WE KNOW: The unexpressed genetic liability to schizophrenia affects cognitive and brain functioning and brain structure. The most prominent impairments in individuals with heightened genetic liability, such as in patients' nonpsychotic relatives, have been measured on executive functioning. Overall gray matter and hippocampal volume are also slightly smaller in the relatives of patients with schizophrenia., As much as I would like genetics to be stronger, these genetic findings are not... 31 Oct 2007.