Schizophrenia Research Forum - A Catalyst for Creative Thinking


Carter CJ. eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull. 2007 Nov 1 ; 33(6):1343-53. Pubmed Abstract

Comments on News and Primary Papers


Primary Papers: eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia?

Comment by:  Chris Carter
Submitted 10 March 2007
Posted 10 March 2007

Supplementary information for this paper is posted on the Polygenic pathways website. This includes a listing of the environmental risk factors associated with bipolar disorder or schizophrenia, which is appended at the bottom of the gene tables for each condition. There is also a page related to the genes in the (eIF2-α kinase signaling network).

For schizophrenia, the environmental risk factors are nicely discussed at the (Schizophrenia.com website). The odds-ratios, as respectable as for any susceptibility gene, are derived from a review by Sullivan, 2005. The recent interest in toxoplasmosis (see SRF Forum Discussion) also emphasizes the importance of environmental influences as risk factors for schizophrenia.

View all comments by Chris Carter