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Swartz MS, Perkins DO, Stroup TS, Davis SM, Capuano G, Rosenheck RA, Reimherr F, McGee MF, Keefe RS, McEvoy JP, Hsiao JK, Lieberman JA, . Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study. Am J Psychiatry. 2007 Mar 1 ; 164(3):428-36. Pubmed Abstract

Comments on News and Primary Papers


Primary Papers: Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study.

Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 10 March 2007
Posted 13 March 2007
  I recommend this paper

One of the surprising findings that John Strauss, John Bartko, and I reported in the 1970s from the International Pilot Study for schizophrenia was the virtually nil relationship between measures of psychosis and functional outcomes. In this regard, one would not predict much effect of antipsychotic drugs on functional outcomes. This report from CATIE supports the view that drug discovery for functional outcomes needs to be based on the elements of schizophrenia most associated with function: cognition and negative symptoms.

References:

Strauss JS, Carpenter WT Jr. Characteristic symptoms and outcome in schizophrenia. Arch Gen Psychiatry. 1974 Apr;30(4):429-34. No abstract available. Abstract

Strauss JS, Carpenter WT. Relationship between predictors and outcome variables:.... Arch Gen Psychiatry. 1974;31:37-42.

Strauss JS, Carpenter WT Jr. Prediction of outcome in schizophrenia. III. Five-year outcome and its predictors. Arch Gen Psychiatry. 1977 Feb;34(2):159-63. Abstract

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