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Carter CJ. Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability. Schizophr Res. 2006 Sep 1 ; 86(1-3):1-14. Pubmed Abstract

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Primary Papers: Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability.

Comment by:  Chris Carter
Submitted 22 July 2006
Posted 25 July 2006

The background data set for this paper, including a list of genes associated with schizophrenia, each with links to ENTREZ, PUBMED, and OMIM can be found at www.polygenicpathways.co.uk. Relationships between susceptibility genes and their protein products are also detailed.

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Primary Papers: Schizophrenia susceptibility genes converge on interlinked pathways related to glutamatergic transmission and long-term potentiation, oxidative stress and oligodendrocyte viability.

Comment by:  Chris Carter
Submitted 10 January 2007
Posted 10 January 2007

I have added a dataset for genes associated with bipolar disorder at Polygenicpathways which I hope will be useful. The dataset lists all genes for which positive association has been reported, and decribes the various interactions of their protein products.

There is of course extreme heterogeneity in gene association studies. However, as is the case in schizophrenia, the bipolar susceptibility candidates are closely related and form elements of clearly-defined signalling networks. When this is the case, multiple interactions between the susceptibility genes may provide a better definition of risk. This is elegantly demonstrated in the paper by Wu and colleagues relating to bladder cancer (Wu et al., 2006).

Many of these bipolar risk genes have also been implicated in schizophrenia. This overlap has already been a subject for a live discussion led by Owen and Craddock in the Schizophrenia Research Forum pages.

There is also a Blog page on the Polygenicpathways site where you are welcome to leave comments or suggestions.

References:

Craddock N, O'Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull. 2006 Jan;32(1):9-16.

Craddock N, Owen MJ. The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry. 2005 May;186:364-6.

Wu X, Gu J, Grossman HB, Amos CI, Etzel C, Huang M, Zhang Q, Millikan RE, Lerner S, Dinney CP, Spitz MR. Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes. Am J Hum Genet. 2006 Mar;78(3):464-79. Epub 2006 Jan 31.

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