Schizophrenia Research Forum - A Catalyst for Creative Thinking

Weinberger DR, Berman KF, Zec RF. Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Arch Gen Psychiatry. 1986 Feb ; 43(2):114-24. Pubmed Abstract
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Primary Papers: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence.

Comment by:  David Lewis, SRF Advisor
Submitted 27 October 2005 Posted 27 October 2005

This seminal investigation demonstrated that dysfunction of the prefrontal cortex, as reflected in reduced cerebral blood flow, was prominent when subjects with schizophrenia were asked to perform certain cognitive tasks.

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