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Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nat Neurosci.
Comments on News and Primary Papers
Comment by: Takao Hensch
Submitted 15 February 2014
Posted 15 February 2014
Our Conte Center is focused on the transcriptome, connectome, and plasticity of PV cells
as the neurodevelopmental basis for mental illness. Their
maturational state dictates the degree of plasticity in developmental critical periods, and
now we know, from Donato et al., in adult learning. Once plasticity is opened by PV cells' function, it closes
when they mature ("high PV" state), including the tightening of the perineuronal nets (PNNs) around them.
In schizophrenia, PV cells may remain in the "low PV" weak PNN state for some time longer than
normal, suggesting, interestingly, that developmental plasticity may be prolonged (i.e., neural circuits fail to stabilize when they normally should). PV cell
maturation may potentially be controlled by Otx2 secreted from the choroid plexus,
which would link enlarged ventricles to impaired PV cells in the brain in schizophrenia (see
Spatazza et al., 2013).
Spatazza J, Lee HH, Di Nardo AA, Tibaldi L, Joliot A, Hensch TK, Prochiantz A. Choroid-plexus-derived Otx2 homeoprotein constrains adult cortical plasticity. Cell Rep. 2013 Jun 27;3(6):1815-23. Abstract
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