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Clarke WP, Chavera TA, Silva M, Sullivan LC, Berg KA. Signalling profile differences: paliperidone versus risperidone. Br J Pharmacol. 2013 Oct ; 170(3):532-45. Pubmed Abstract

Comments on News and Primary Papers


Primary Papers: Signalling profile differences: paliperidone versus risperidone.

Comment by:  Bryan Roth, SRF Advisor
Submitted 12 July 2013
Posted 14 July 2013
  I recommend this paper

This is an interesting paper from a cell signaling perspective. It demonstrates that even very small changes in ligand structure—in this case, a single hydroxyl—can lead to rather substantial changes in intracellular signaling pathways.

View all comments by Bryan Roth