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Thomson PA, Parla JS, McRae AF, Kramer M, Ramakrishnan K, Yao J, Soares DC, McCarthy S, Morris SW, Cardone L, Cass S, Ghiban E, Hennah W, Evans KL, Rebolini D, Millar JK, Harris SE, Starr JM, Macintyre DJ, , McIntosh AM, Watson JD, Deary IJ, Visscher PM, Blackwood DH, McCombie WR, Porteous DJ. 708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits. Mol Psychiatry. 2013 Jun 4 ; Pubmed Abstract

Comments on News and Primary Papers


Primary Papers: 708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.

Comment by:  Bryan Roth, SRF Advisor
Submitted 8 June 2013
Posted 10 June 2013
  I recommend this paper

This is an important, albeit somewhat negative, study examining common and rare DISC1 variants. The authors report no significant apparent association with schizophrenia, although potential associations with depression and cognition merit examination and replication.

The main value of the paper is that it is the most extensive effort thus far examining DISC1 variants in schizophrenia and, in agreement with many of the more recent studies, no robust linkage to schizophrenia is reported.

View all comments by Bryan Roth