Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K.
Structural and molecular interrogation of intact biological systems. Nature.
2013 Apr 10
Comments on News and Primary Papers
Comment by: Karoly Mirnics, SRF Advisor
Submitted 10 April 2013
Posted 10 April 2013
The Deisseroth lab has done it again! This is an amazing technical advance that can revolutionize the way we do histology and microcircuitry studies. Also, this will be very relevant for human postmortem research, as it will allow better 3-D understanding of the local connectivity. The pictures are very impressive, although I have some potential concerns with the antibody penetration, at least in some cases. In addition, it is noteworthy that this technology will require additional, non-trivial investment in equipment, and it might be (at least initially) best suited for core facilities.
View all comments by Karoly MirnicsComment by: Philip Seeman (Disclosure)
Submitted 11 April 2013
Posted 12 April 2013
Ramón y Cajal is alive and well, but renamed Karl Deisseroth.
View all comments by Philip Seeman