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Demontis D, Nyegaard M, Buttenschøn HN, Hedemand A, Pedersen CB, Grove J, Flint TJ, Nordentoft M, Werge T, Hougaard DM, Sørensen KM, Yolken RH, Mors O, Børglum AD, Mortensen PB. Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk. Am J Med Genet B Neuropsychiatr Genet. 2011 Dec ; 156B(8):913-22. Pubmed Abstract

Comments on News and Primary Papers


Primary Papers: Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk.

Comment by:  Karoly Mirnics, SRF Advisor
Submitted 26 September 2011
Posted 26 September 2011
  I recommend this paper

I like this study, as it nicely combines genetic studies of NMDA receptor encoding genes with the role of potential environmental factors (in this case, measured by HSV-2 seropositivity) in disease pathophysiology. Such studies are few, to date, even though it is certain that the response to infection is strongly determined by our genetic make-up. But, how is this interaction occurring? This should be a topic of very interesting follow-up experiments, assuming that this pathophysiological-genetic interaction can be recapitulated in an in-vivo or in-vitro model.

View all comments by Karoly Mirnics