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Andreasen NC, Wilcox MA, Ho BC, Epping E, Ziebell S, Zeien E, Weiss B, Wassink T. Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry. 2011 Aug 30 ; Pubmed Abstract

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Primary Papers: Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes.

Comment by:  Karoly Mirnics, SRF Advisor
Submitted 2 September 2011
Posted 7 September 2011
  I recommend this paper

This approach is noteworthy—in the fashionable world of CNVs, we must not forget our previous SNP findings. Modeling epistasis between genes should be a priority, yet there are very few approaches and publications in this arena (compared to the number of publication on single gene effects). It is also nice to see that data replicate, and that we see the usual suspects, including PDE4B, RELN, ERBB4, DISC1, and NRG1.

View all comments by Karoly Mirnics