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Hyde TM, Lipska BK, Ali T, Mathew SV, Law AJ, Metitiri OE, Straub RE, Ye T, Colantuoni C, Herman MM, Bigelow LB, Weinberger DR, Kleinman JE. Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci. 2011 Jul 27 ; 31(30):11088-95. Pubmed Abstract

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Primary Papers: Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.

Comment by:  Patricio O'Donnell, SRF Advisor
Submitted 10 August 2011
Posted 10 August 2011
  I recommend this paper

Very interesting report of developmental (pre- and postnatal) changes in several markers of GABA function in the prefrontal cortex of a large cohort of normal humans. The observation of developmental switches in the expression of genes (GAD25 to GAD67 and NKCC1 to KCC2) may be of importance in the peri-adolescent acquisition of abnormal interneuron function that has been proposed in schizophrenia.

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