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Wang L, Lockstone HE, Guest PC, Levin Y, Palotás A, Pietsch S, Schwarz E, Rahmoune H, Harris LW, Ma D, Bahn S. Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia. J Proteome Res. 2010 Jan ; 9(1):521-7. Pubmed Abstract

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Primary Papers: Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia.

Comment by:  John McGrath, SRF Advisor
Submitted 26 November 2009
Posted 28 November 2009
  I recommend this paper

This study examines fibroblast cell cultures from people with schizophrenia versus controls. The authors found alterations in gene expression, protein abundance, and a functional assay related to cell proliferation (incorporation of tritiated thymidine). Bioinformatic analysis of the results from the gene array study also suggested disruption of the cell cycle process.

The use of cell cultures (e.g. lymphoblastoid cell lines, fibroblast, olfactory neuroepithelium) in biological psychiatry may help us gain traction on altered pathways associated with disease processes.

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