Riley B, Thiselton D, Maher BS, Bigdeli T, Wormley B, McMichael GO, Fanous AH, Vladimirov V, O'Neill FA, Walsh D, Kendler KS.
Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample. Mol Psychiatry.
2010 Jan 1
Comments on News and Primary Papers
Primary Papers: Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample.Comment by: David J. Porteous, SRF Advisor
Submitted 28 October 2009
Posted 29 October 2009
I recommend this paper
Sorting wheat from chaff in genomewide association studies may well entail more time and effort than the original study. It is therefore important to critically evaluate results from truly independent data sets and, as this study attempts, to take the analysis beyond just statistical association toward some sort of functional analysis. That said, this would appear to be a fairly dramatic example of winner's curse, for the strength of association reported in the Irish sample would not have warranted even the briefest mention in the original Cardiff study (O'Donovan et al., 2008).
O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR; Molecular Genetics of Schizophrenia Collaboration. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 2008 Sep;40(9):1053-5. Abstract
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