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Juvonen H, Reunanen A, Haukka J, Muhonen M, Suvisaari J, Arajärvi R, Partonen T, Lönnqvist J. Incidence of schizophrenia in a nationwide cohort of patients with type 1 diabetes mellitus. Arch Gen Psychiatry. 2007 Aug ; 64(8):894-9. Pubmed Abstract
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Comment by:  Jürgen Zielasek
Submitted 20 August 2007 Posted 20 August 2007
  I recommend the Primary Papers

This is an interesting epidemiological finding. A reproduction of this association in other populations would be needed. Of note, one of the autoantigens of type I diabetes (GAD, glutamic acid decarboxylase) is expressed in the nervous system and autoantibodies against GAD lead to a rare neurological disorder, Stiff-Person-Syndrome. Immunologically, type I diabetes is very complex, involving cellular and humoral immune effector mechanisms. How this may protect against the development of schizophrenia is not easily explained.

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