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Denier C, Orgibet A, Roffi F, Jouvent E, Buhl C, Niel F, Boespflug-Tanguy O, Said G, Ducreux D. Adult-onset vanishing white matter leukoencephalopathy presenting as psychosis. Neurology . 2007 May 1 ; 68(18):1538-9. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Daniel StewartKenneth Davis
Submitted 19 June 2007 Posted 19 June 2007

Adult-onset VWM disease, as noted by the authors, is a leukodystrophy that can present with psychosis and can be misdiagnosed as schizophrenia. We examined its related disease ¬metachromatic leukodystrophy¬in in our original hypothesis paper on white matter in schizophrenia (Davis et al., 2003). The parallels between demyelinating diseases that affect the brain regionally (i.e., frontal and temporal lobes) and schizophrenia are quite striking, as is the fact that psychosis is the presentation only when the disease presents in young adulthood, concurrent with when one would expect schizophrenia to make its appearance phenotypically. This type of anecdotal evidence is helpful in connecting the presentation of schizophrenia-like symptoms to a real-world deficit in white matter that is macroscopic, since in schizophrenia the deficits in white matter are only revealed either by advanced imaging techniques (Kubicki et al., 2005) or at the ultra-structural (  Read more

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