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Annotation

Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ. A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry . 2007 May 8 ; PubMed Abstract

Comments on Paper and Primary News
Comment by:  Todd Lencz
Submitted 10 May 2007 Posted 10 May 2007

In the last two years, whole genome association (WGA) studies have identified new candidate genes for several complex diseases, including age-related macular degeneration, diabetes, inflammatory bowel disease, and myocardial infarction. Initial reports have now been published in Molecular Psychiatry for schizophrenia (Lencz et al., 2007) and bipolar disorder (Baum et al., 2007), and several national and international consortia are currently planning or performing very large-scale studies in both disorders. Thus, it is timely to begin considering the potential implications of these investigations.

In their current paper, Baum et al. (2007) present data consistent with a polygenic, common disease/common variant model. No genetic variants of large effect were detected, although the authors duly note that the limitations of the current generation of microarray technology, as well as their pooling approach to genotyping, make a definitive statement premature. For example, the Illumina platform utilized in this study does not cover the pseudoautosomal region that we identified...  Read more


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Comment by:  Nick Craddock
Submitted 10 May 2007 Posted 10 May 2007
  I recommend this paper

This paper describes a large, well-conducted, two-stage genetic association study of bipolar disorder using a DNA pooling approach. A genome-wide set of over 500,000 SNPs (Illumina platform) was used in a U.S. discovery sample of 460 cases and 560 controls and 1,877 SNPs were taken forward into a pooling replication experiment in a German sample of 772 cases and 876 controls. The 88 SNPs showing evidence for association in the same direction in both the U.S. and German pools were then typed individually in all the samples. Four SNPs showed combined evidence for association at p This study demonstrates the potential utility of genome-wide association approaches and points to several loci that may influence susceptibility to bipolar disorder. Because of the modest effect sizes of the loci and the oligogenic/polygenic nature of mood and psychotic illness it will be crucial for the reproducibility and generalizability of such findings to be tested...  Read more


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Comment by:  Chris Carter
Submitted 12 May 2007 Posted 13 May 2007
  I recommend this paper
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