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Roig B, Virgos C, Franco N, Martorell L, Valero J, Costas J, Carracedo A, Labad A, Vilella E. The discoidin domain receptor 1 as a novel susceptibility gene for schizophrenia. Mol Psychiatry . 2007 Sep 1 ; 12(9):833-41. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Mary Reid
Submitted 27 September 2007 Posted 27 September 2007

Roig and colleagues propose that DDR1 (discoidin domain receptor 1) is a new susceptibility gene for schizophrenia. It's of interest that it has been shown to bind SHP-2. (Wang et al., 2006). In view of the fact that Roig describes DDR1 as a myelin gene, and PZR (protein zero related) is a proposed substrate of SHP-2, might we suspect disruption of SHP-2 signaling in schizophrenia (Zhao et al., 1998)?

Activating mutations of SHP-2 are found in Noonan syndrome, in which both autism and schizophrenia have been reported. De Hert et al. found high levels of Helicobacter pylori in institutionalized schizophrenic patients (De Hert et al., 1997), and it would seem relevant that SHP-2 is activated by complex formation with Helicobacter pylori CagA. Might bacterial eradication result in the alleviation of symptoms of schizophrenia? Is it likely that periods of extreme stress predispose to gastric ulceration with a subsequent...  Read more

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