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Gottesmann C, Gottesman I. The neurobiological characteristics of rapid eye movement (REM) sleep are candidate endophenotypes of depression, schizophrenia, mental retardation and dementia. Prog Neurobiol . 2007 Mar 1 ; 81(4):237-50. PubMed Abstract

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Comment by:  Arun Sasi
Submitted 18 October 2010 Posted 18 October 2010
  I recommend this paper

It is a wonderful concept. But I wonder whether REM in schizophrenia patients matches their waking EEG?

View all comments by Arun Sasi

Comment by:  Claude Gottesmann
Submitted 21 October 2010 Posted 21 October 2010

In reply to Dr. Sasi: From the psychological standpoint, there are strong similarities between dreaming and schizophrenia. Indeed, dreaming is characterized by "sensory hallucinations, bizarre imagery, diminished reflective awareness, orientational instability, intensification of emotion and instinctual behaviors" (Hobson et al., 1998), which strongly resemble schizophrenic symptoms.

From the neurobiological standpoint, there are now 14 similarities between dreaming and schizophrenia:

1. During REM sleep there is no alpha rhythm. In schizophrenia, during waking there is a strong deficit of alpha rhythm (Stassen et al., 1999). In a relaxing-chair situated in a soundproof room, the schizophrenic patient shows nearly no alpha rhythm contrary to normals. This is an index of decrease of habituation processes related to central inhibition deficit.

2. The gate control is disturbed during REM sleep. The recovery cycle of the auditory N100 component of the evoked potential is...  Read more

View all comments by Claude Gottesmann
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