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Annotation

Carter CJ. eIF2B and oligodendrocyte survival: where nature and nurture meet in bipolar disorder and schizophrenia? Schizophr Bull . 2007 Nov 1 ; 33(6):1343-53. PubMed Abstract

Comments on Paper and Primary News
Comment by:  Chris Carter
Submitted 10 March 2007 Posted 10 March 2007

Supplementary information for this paper is posted on the Polygenic pathways website. This includes a listing of the environmental risk factors associated with bipolar disorder or schizophrenia, which is appended at the bottom of the gene tables for each condition. There is also a page related to the genes in the (eIF2-α kinase signaling network).

For schizophrenia, the environmental risk factors are nicely discussed at the (Schizophrenia.com website). The odds-ratios, as respectable as for any susceptibility gene, are derived from a review by Sullivan, 2005. The recent interest in toxoplasmosis (see SRF Forum Discussion) also emphasizes the importance of environmental influences as risk...  Read more


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