Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.

Swartz MS, Perkins DO, Stroup TS, Davis SM, Capuano G, Rosenheck RA, Reimherr F, McGee MF, Keefe RS, McEvoy JP, Hsiao JK, Lieberman JA, . Effects of antipsychotic medications on psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study. Am J Psychiatry . 2007 Mar 1 ; 164(3):428-36. PubMed Abstract

Comments on Paper and Primary News
Comment by:  William Carpenter, SRF Advisor (Disclosure)
Submitted 10 March 2007 Posted 13 March 2007
  I recommend this paper

One of the surprising findings that John Strauss, John Bartko, and I reported in the 1970s from the International Pilot Study for schizophrenia was the virtually nil relationship between measures of psychosis and functional outcomes. In this regard, one would not predict much effect of antipsychotic drugs on functional outcomes. This report from CATIE supports the view that drug discovery for functional outcomes needs to be based on the elements of schizophrenia most associated with function: cognition and negative symptoms.


Strauss JS, Carpenter WT Jr. Characteristic symptoms and outcome in schizophrenia. Arch Gen Psychiatry. 1974 Apr;30(4):429-34. No abstract available. Abstract

Strauss JS, Carpenter WT. Relationship between predictors and outcome variables:.... Arch Gen Psychiatry. 1974;31:37-42.

Strauss JS, Carpenter WT Jr. Prediction of outcome in schizophrenia. III. Five-year outcome and its predictors. Arch Gen Psychiatry. 1977 Feb;34(2):159-63. Abstract

View all comments by William Carpenter

Submit a Comment on this Paper
Make a comment on this paper. 

If you already are a member, please login.
Not sure if you are a member? Search our member database.

*First Name  
*Last Name  
Country or Territory  
*Login Email Address  
*Confirm Email Address  
*Confirm Password  
Remember my Login and Password?  
Get SRF newsletter with recent commentary?  
Enter the code as it is shown below:
This code helps prevent automated registrations.

I recommend this paper

Please note: A member needs to be both registered and logged in to submit a comment.


(If coauthors exist for this comment, please enter their names and email addresses at the end of the comment.)


SRF News
SRF Comments
Text Size
Reset Text Size
Email this pageEmail this page

Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright