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Crow TJ. How and why genetic linkage has not solved the problem of psychosis: review and hypothesis. Am J Psychiatry . 2007 Jan 1 ; 164(1):13-21. PubMed Abstract

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Comment by:  Karl-Ludvig Reichelt (Disclosure)
Submitted 8 March 2007 Posted 8 March 2007
  I recommend this paper

Genetics in Schizophrenia
It is reasonably certain that the genetic disposition must be polygenomic and on different chromosomes (Craddock et al., 2005). It is, however, proteins and fragments of proteins (peptides) that usually are the active or inactivated chemical compound in genetic disorders. Thus, enzymes, enzyme-binding proteins, membrane transporters and receptors, and modifying peptides are the active executive compounds of the genetic disposition (Parker and Steitz, 1997; Cooper and Stevens, 1995). Since DNA exons are differentially expressed, crossing over and deletions occur, and siRNA and methylation regulate transcription also in an epigenetic way, it is critical to find the proteins/peptides involved. mRNA is extensively edited and even proteins undergo splicing (see   Read more

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