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Annotation

Camargo LM, Collura V, Rain JC, Mizuguchi K, Hermjakob H, Kerrien S, Bonnert TP, Whiting PJ, Brandon NJ. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Mol Psychiatry . 2007 Jan 1 ; 12(1):74-86. PubMed Abstract

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Comment by:  Akira Sawa, SRF Advisor
Submitted 28 October 2006 Posted 28 October 2006

DISC1 is a promising risk factor for schizophrenia and mood disorders. DISC1 may also be involved in cognitive dysfunction associated with aging. Recent studies have suggested that DISC1 is multifunctional, with various isoforms (indeed, there are many more kinds of DISC1 isoforms than already published). An outstanding paper by Camargo, Brandon, and colleagues approached this fascinating, but complicated, molecule with a very unique approach. The authors conducted several sets of yeast two-hybrid screening with DISC1 and related proteins as baits, analyzed the experimental data with sophisticated bioinformatic methods, and generated a “DISC1 interactome map.”

The map is consistent with previous experimental reports. More importantly, it suggests a role for DISC1 in synaptic maturation and regulation. DISC1 and dysbindin, another promising risk factor for schizophrenia, share common protein-protein interactions, suggesting that these two risk factors may be in the same disease pathway. At the Society for Neuroscience meeting held in Atlanta last week, several groups...  Read more


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